San Francisco Giants vs San Diego Padres Predictions Today | Best MLB Picks For 8/20/25

San Francisco Giants vs San Diego Padres Predictions Today | Best MLB Picks For 8/20/25

If you are looking for MLB picks, predictions and best bets for today’s San Francisco Giants vs San Diego Padres matchup, we have you covered! Our MLB handicapping experts discuss the spread and total from a sports betting perspective, sharing their picks and predictions vs the current odds.

#mlbpicks #mlbpredictions #mlbpickstoday

⚾️ San Francisco Giants vs San Diego Padres Betting Preview 8/20/25

Game Details
Date & Time: Monday, August 18, 2025 — 6:40 PM PT (9:40 PM ET)

Venue: Petco Park, San Diego, CA — home of the #Padres
New York Post

How to Watch
TV Broadcast: MLB Network. Available regionally on NBC Sports Bay Area for Giants fans and on Padres TV for San Diego viewers.

Radio: Giants coverage on KNBR 680 AM / 104.5 FM, and Padres radio on KSFN 1510 AM.

Streaming: Accessible via authenticated RSN apps, MLB.TV, and national streaming platforms where available.

Team Twitter Hashtags
#Giants | #Padres

Betting Lines & Total
Moneyline: Padres –155 | Giants +130
Over/Under Total (O/U): 7.5 runs

Interesting Storylines & Team Highlights

Starting Pitchers:
Giants: Right-hander Landen Roupp, with a 3.45 ERA and 100 strikeouts over 104.1 innings.

Padres: Lefty JP Sears, sporting a 5.12 ERA across 17.1 innings and 101 strikeouts over 116 innings pitched.

Divisional Context: This game kicks off a four-game NL West showdown between two key standings competitors — Padres are in second in the division (70–56), while the Giants maintain a playoff chase (61–65).

Padres Dominance in Season Series: San Diego leads this season’s matchup against San Francisco with a strong 7–3 record before this game.

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