St. Louis Cardinals vs Tampa Bay Rays Predictions Today | Best MLB Picks For 8/21/25

St. Louis Cardinals vs Tampa Bay Rays Predictions Today | Best MLB Picks For 8/21/25

If you are looking for MLB picks, predictions and best bets for today’s St. Louis Cardinals vs Tampa Bay Rays matchup, we have you covered! Our MLB handicapping experts discuss the spread and total from a sports betting perspective, sharing their picks and predictions vs the current odds.

#mlbpicks #mlbpredictions #mlbpickstoday

St. Louis Cardinals @ Tampa Bay Rays • August 21, 2025 • MLB Regular Season

** First Pitch:**
Thursday, August 21, 2025 — 7:35 PM ET at George M. Steinbrenner Field, Tampa, FL

How to Watch:

TV Broadcast: Coverage available on FSUN (Florida Sports Network) and FDSN MW (Midwest region)

Streaming (Out-of-Market): Available via MLB.tv, fuboTV (baseball package), or MLB.TV Amazon Channel

Betting Lines (As of Game Day):

Run Line (Spread): Cardinals −1.5
Total (Over/Under): 8.5 runs

Team & Venue Context:

This game was rescheduled to August 21 at 7:35 PM ET (originally Aug 23) to avoid a conflict with the Tampa Bay Buccaneers’ preseason game across the street

The Rays are hosting at George M. Steinbrenner Field, the Yankees’ spring training facility, due to damage at Tropicana Field from Hurricane Milton

Team Twitter Hashtags:

St. Louis Cardinals: #STLCards, #Cardinals
Tampa Bay Rays: #RaysUp, #RaysBaseball

Interesting Facts:

Cardinals Performance: As of this matchup, the Cardinals held a 63‑65 record and were competing in the NL Central under manager Oliver Marmol

Rays Performance: The Rays held a 61‑66 record in the AL East, managed by Kevin Cash

Interleague Context: This is an interleague matchup with both teams navigating tough mid‑season slumps—Cardinals just under .500, Rays adjusting to temporary facilities

#stlouiscardinals vs #tampabayrays

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