The San Francisco 49ers will break the tie with a narrow victory, leveraging home-field advantage at Levi's Stadium and a stout defense to contain Kyler Murray despite recent Cardinals success (including a 47-24 playoff rout in January 2025).

12 comments

  1. The cardinals are cheeks on both sides of the ball with their injuries included. For that reason, I expect nfc west shenanigans to happen and AZ to win by 2 scores

  3. Niners got this. Cmon man. Mac can win against the Cardinals. They’re in for a surprise with our new run defense……just saying!

  5. No idea why they’ve done so well over the years against us. It’s like Steelers v Browns. Browns have always done well for no reason.

  6. We are better than them most times but Kyler Murray always has some crazy run against us. Then we have some back breaking turnover. I hate the Rams and Seahawks more but Cardinals games actually stress me out the most.

  7. It seems every time they play us they win two in a row. Hopefully that’s not the case here

  9. off topic, this game is kinda special for me. good friend and big cards fan passed away recently (50). I‘m gonna miss the friendly rivalry and the bad jokes. RIP Scotty! Go Niners!

  10. TBH I think they take this one and we win the one in November. Early season Kyler > mid/late season Kyler, we should have more weapons back by then, and even with the Cardinals’ secondary banged up I’m not sure I trust Mac against the their D-line (his pressure-to-sack ratio last week was *bad;* I have no doubt Gannon is watching that film and grinning). I would love to be proven wrong about this game though.

  11. Man, the cardinals have a secondary only by the most technical definition. I’m cautious but confident

  12. Bryce looked good other than that one pick six last week. Don’t see why Mac can’t do the same against a more depleted defense

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