San Francisco 49ers vs. Tampa Bay Buccaneers Pick 10/12/25 NFL Week 6 Pick Prediction
49ers and Buccaneers going off on Sunday. All right, here we got 49er quarterback and receiver Pearson all out are out. Receiver Jenny’s out. Also out of receivers Aayuk and Taylor and Watkins out on defense Bosa on and the tackle Nickelback questionable. Tampa Bay running back Irving. Receivers Evans and Godwin out on defensive corners out. San Francisco has a slight injury advantage based on the child ratings. The Bucks offense has the lowest out rating at 68. San Francisco improved to 4-1 after a 26-23 road win at LA Rams. The 49ers were limited on the ground but moved the football through the air. They limited the Rams ground attack and allowed 378 yards passing for eight yards per pass attempt. San Francisco benefited by Rams coaching blunders and player miscus. M Jones completed 33 of 49 passing for 342 yards and two touchdowns. He bay 4-1 a 3835 road win at Seattle. The Bucks rushed for 2.4 yards a carry but were effective in the passing game. They did a poor job in both rush and pass defense. Baker Mayfield 29 of 333 passing for 379 yards and two touchdowns. 49ers passing game on the road has averaged 69% completion rate for seven yards per pass attempt. On defense on the road they held opponents to 3.9 yards per rush, 6.8 yards per pass attempt. Hemp Bay’s offense at home rushing for under four yards a carry and struggles with quarterback accuracy. The Bucks defense at home averaging 68% completion rate. 49ers 5 and three the spread on the road against winning teams. Bucks three and five the spread home against winning teams. Pick here San Francisco plus three and a half.
San Francisco 49ers vs. Tampa Bay Buccaneers Pick 10/12/25 NFL Week 6 Pick Prediction
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