College football Week 5 continues Friday night with three more games, following two on Thursday, and every one of them is on TV tonight. It’s also Flex Friday on PrizePicks — meaning you get your money back when you lose.

Friday’s Week 5 college football schedule kicks off at 7 p.m. ET with two games: Pittsburgh vs. Virginia Tech (VT -2.5) on ESPN and Liberty (-6.5) vs. Delaware on CBS Sports Network. Then Penn State (-2.5) visits Northwestern at 8 p.m. ET on FOX to close the night.

There’s no marquee matchup on this Friday slate, but the spreads are tight. Two of the three games sit at 2.5 points, including an ACC showdown between 4-0 Pitt and 4-0 Virginia Tech and the first game ever at the new Ryan Field.

Below is the full Week 5 college football schedule for Friday’s games, how to watch or stream every NCAAF game, and current spreads via PrizePicks Team Picks — now available in 35 states!

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Friday College Football Games Today: Week 5 Schedule, TV Channels, & Spreads

All game times are in Eastern Time. Spreads and winner payouts are live on PrizePicks Team Picks as of posting, but are subject to change.

Payouts below — like 2x — represent real-money multipliers on correct picks on PrizePicks Team Picks at the time of writing. For example, a $10 entry on Virginia Tech to win at a 1.69x multiplier would pay out an estimated $16.90 if you’re right.

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Make college football picks against the spread on PrizePicksHow to Watch College Football Games Tonight – Friday, October 2

With kickoffs at 7:00 and 8:00 p.m. ET, tonight’s three-game slate spans three networks. ESPN has Pittsburgh-Virginia Tech, CBS Sports Network has Liberty-Delaware, and FOX has Penn State-Northwestern. Liberty-Delaware carries the biggest spread of the night at 6.5 points.

The 8:00 p.m. ET kickoff is the nightcap. Penn State and Northwestern both enter off Big Ten losses, and each is hunting its first conference win, with the Nittany Lions favored by 2.5 on FOX. Before that, Pitt and Virginia Tech put their 4-0 starts on the line at Lane Stadium in Blacksburg.

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Flex Friday on PrizePicks: Run It Back on Your Friday Lineups

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How to Watch Pittsburgh vs. Virginia Tech – Friday, October 2

Pittsburgh vs. Virginia Tech is set for a 7:00 p.m. ET kickoff on ESPN at Lane Stadium in Blacksburg. Virginia Tech is a 2.5-point favorite on the spread, with a 1.69x payout to win outright (2.08x for Pittsburgh), according to PrizePicks.

Both teams are 4-0, so someone takes a first loss. The Hokies, who went 3-9 last season, averaged 50.7 points through their first three games. Pitt’s defense gave up just 11.3 per game over the same stretch.

How to Watch Liberty vs. Delaware – Friday, October 2

Liberty vs. Delaware is set for a 7:00 p.m. ET kickoff on CBS Sports Network. Liberty is a 6.5-point favorite on the spread, with a 1.36x payout to win outright (3.03x for Delaware), according to PrizePicks.

It’s the Conference USA opener for both teams, played at Delaware Stadium in Newark on Parents & Family Weekend. Liberty won the first meeting last season, 59-30, and comes in off a 34-17 win at Coastal Carolina.

How to Watch Penn State vs. Northwestern – Friday, October 2

Penn State vs. Northwestern is set for an 8:00 p.m. ET kickoff on FOX at Ryan Field in Evanston. Penn State is a 2.5-point favorite on the spread, with a 1.66x payout to win outright (2.12x for Northwestern), according to PrizePicks.

This is the first game at the new Ryan Field. Penn State, in its first season under Matt Campbell, lost 24-20 at home to Wisconsin last week, and Northwestern fell 29-23 at #5 Indiana. Northwestern also won last year’s meeting, 22-21.

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More Friday College Football Picks Today

Need some research before you lock in your college football lineup today? Tap into the Playbook’s Week 5 CFB coverage from our experts:

Stay locked in on the Playbook college football home for daily picks, research, and game previews throughout the 2026 college football season.

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