Los Angeles Dodgers vs San Diego Padres Predictions Today | Best MLB Picks For 8/22/25

If you are looking for MLB picks, predictions and best bets for today’s Los Angeles Dodgers vs San Diego Padres matchup, we have you covered! Our MLB handicapping experts discuss the spread and total from a sports betting perspective, sharing their picks and predictions vs the current odds.

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Los Angeles Dodgers @ San Diego Padres • August 22, 2025 • MLB Regular Season

⏱ First Pitch:
Friday, August 22, 2025 — 9:40 PM ET / 6:40 PM PT, held at Petco Park, San Diego

How to Watch

TV Broadcast:

SportsNet LA (SNLA) for Dodgers fans

SDPA (San Diego Padres Network) for Padres markets

Streaming & Out-of-Market:

Check local platforms, MLB.tv, Apple TV+, ESPN, FS1, TBS, or Roku depending on region

Betting Snapshot

Moneyline: Dodgers –125 (favored), Padres +105 (underdogs)
Run Line: Dodgers –1.5
Total (Over/Under): 8 runs (Over –106, Under –115)

Team Hashtags

Los Angeles Dodgers: #Dodgers, #LADodgers
San Diego Padres: #Padres, #PadresBaseball

Interesting Facts & Context

Interstate Rivalry: This is part of a long-standing “I‑5 rivalry”—a classic Southern California MLB matchup along Interstate 5, with divisional implications and regional pride on the line

Recent Tensions: Their rivalry heated up in June 2025 with high-tension incidents: Dodgers’ Andy Pages was hit by a pitch from Dylan Cease, and a benches-clearing episode followed a confrontation involving manager shoving and players getting hit during games

Dodgers’ Moneyline Trends: As favorites at –125, Dodgers have won roughly 59% of those games, reflecting consistent performance when favored, according to recent betting data

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6 comments

  2. Starting pitcher for SDP, Mr. Yu Darvish ought to have a splendid game vs. LAD
    Former start he looked sluggish giving out 4 runs bottom of the 1st to hurt my feelings.
    I'm with Yu-san and San Diego Padres + 110, rolled 6 for 6 ats/ml yesteray evening, and currently riding a 7 – 0 win streak ats
    with Pre-Season exhibition games. Give me Padres + 110 on their Moneyline…Muchas Gratious amego😍

  5. Yu – san shares similar hybrid to me we're both a Japanese hybrid.
    Yu Darvish (39) is capable of putting on a splendid performance till 7th inning when he's on Fire.
    Opinions vary Marcus, good luck with your wager tonight

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