Pittsburgh Pirates vs St. Louis Cardinals Predictions Today | Best MLB Picks For 8/27/25

If you are looking for MLB picks, predictions and best bets for today’s Pittsburgh Pirates vs St. Louis Cardinals matchup, we have you covered! Our MLB handicapping experts discuss the spread and total from a sports betting perspective, sharing their picks and predictions vs the current odds.

#mlbpicks #mlbpredictions #mlbpickstoday

Pittsburgh Pirates vs St. Louis Cardinals • August 27, 2025 • MLB Regular Season

First Pitch & Venue

First Pitch: Wednesday, August 27, 2025 — 7:45 PM ET
Location: Busch Stadium, St. Louis, Missouri

How to Watch

TV Coverage:

FOX Sports 1 (national)
FDSMW (St. Louis regional coverage)
SportsNet Pittsburgh (in-market for Pirates fans)

Team Twitter Hashtags

Pittsburgh Pirates: #Pirates
St. Louis Cardinals: #Cardinals

Betting Snapshot

Moneyline Odds:

Cardinals: –179 (favored)
Pirates: +148 (underdogs)
Run Line: Cardinals –1.5
Total Runs (Over/Under): 7.5 runs

Interesting Facts & Context

Cy Young Watch: Pirates’ ace Paul Skenes is currently a frontrunner for the 2025 NL Cy Young Award, boasting a franchise-best 195 ERA+ thanks to 11 scoreless starts. He is notably not scheduled to pitch in this opener.

St. Louis at Home: The Cardinals look to snap a five-game home losing streak as they welcome the Pirates to Busch Stadium.

Emerging Pirates Talent: Despite offensive struggles—including a team wRC+ of just 82—the Pirates’ lineup has seen bright spots from Jared Triolo (wRC+ 135 in second half) and Tommy Pham (wRC+ 136), offering hope for improved offensive consistency.

👍 Make sure to SUBSCRIBE to WagerTalk TV; 🔔 CLICK the Bell and never miss an episode!

⚾️ More Free MLB Picks: https://www.wagertalk.com/free-sports-picks/MLB
🤑 Free Sports Picks: https://www.wagertalk.com/free-sports-picks
📊 Live Odds: https://www.wagertalk.com/odds
🗞️ News: https://www.wagertalk.com/news

👍 Stay connected with WagerTalk

📺 YouTube: https://wt.buzz/tv
👍 Facebook: https://wt.buzz/fb
🐦 Twitter: https://wt.buzz/tw
📸 Instagram: https://wt.buzz/ig
📰 Reddit: https://wt.buzz/rd
❤️ iHeart Radio: https://wt.buzz/iheart
🍎 Apple Podcasts: https://wt.buzz/ap
📌 Pinterest: https://wt.buzz/pin

9 comments

  4. How anyone could call you lucky or bash you is baffling. You’ve been crushing going back to the NBA playoffs. Made me a lot of money. Always great analysis. One of the reasons I go to Wagertalk.

  5. Not to mention Jesse, the Cardinals when they do win are the king of 1 run victories. Even when they were above .500 they had a negative run differential. I think Pittsburgh will most likely get to Gray. The Cards are too volatile. I think this is a winner but the RL is too juiced for me atp. Good luck my friend. Great pick yesterday!

Leave a Reply