Oddsmakers give the Louisville Cardinals (3-0) the edge when they visit the Pittsburgh Panthers (2-1) on Saturday, September 27, 2025 in a matchup between ACC foes at Acrisure Stadium. Louisville is favored by 4.5 points.
Facing the Bowling Green Falcons in their last contest, the Cardinals won 40-17.
The Panthers lost to the West Virginia Mountaineers, 31-24, in their last contest.
Bet now!Louisville vs. Pittsburgh Predictions
For insights on the upcoming game between the Louisville Cardinals and Pittsburgh Panthers, computer-calculated against-the-spread, over/under, and score predictions are below, per Dunkel Index.
Pick ATS: Panthers (+ 4.5)Pick OU:
Over (57.5)
Prediction:
Panthers 30 – Cardinals 29
Bet now on FanDuel Sportsbook!
Louisville vs. Pittsburgh Moneylines
Take a peek below at the most recent moneylines for the Cardinals-Panthers matchup.
Louisville Moneyline: -189Pittsburgh Moneyline: +157
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Louisville Betting InsightsLouisville has won all three of the games it has been favored on the moneyline this season.Louisville has played three times as a moneyline favorite with odds of -189 or shorter, and claimed a victory in each game.Cardinals games have gone over 57.5 points just once this season (in three outings).The average point total in Cardinals games this season is 54.5, 3.0 points fewer than this matchup’s over/under.The Cardinals score the 61st-most points in college football this season, while the Panthers’ offense racks up the 40th-most.Pittsburgh Betting InsightsPittsburgh will play as the underdog for the first time this season.Pittsburgh has not entered a game this season as a bigger underdog on the moneyline than the +157 odds on them winning this game.Pittsburgh has combined with its opponent to score more than 57.5 points just twice this season.The average total for Pittsburgh’s games this season is 53.8 points, 3.7 fewer points than this game’s over/under.
Watch Louisville vs. Pittsburgh on Fubo.
Key Stats for Louisville vs. PittsburghOver their last three meetings, Louisville has tallied two wins against Pittsburgh.In those games against Pittsburgh, the Cardinals have covered two times while eclipsing the point total on one occasion.The Cardinals rank 58th in total offense this season (415.0 yards per game), but they’ve been thriving on the defensive side of the ball, ranking 16th-best in the FBS with 415.0 yards allowed per game.Louisville is averaging 39.7 points per game on offense this year (28th in the FBS), and is giving up 16.0 points per game (29th) on the other side of the ball.The Panthers rank 53rd with 424.3 total yards per game on offense, and they rank 32nd with 286.3 total yards surrendered per game on the defensive side of the ball.Pittsburgh’s offensive attack has been leading the charge for the team, as it ranks 17th-best in the FBS with 43.3 points per game. In terms of defense, it is ceding 19.0 points per game, which ranks 45th.
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