Blackpool beat Aston Villa’s Under-21 side while Port Vale put five past Manchester City in Tuesday’s EFL Trophy action.
Everton also lost at Shrewsbury Town, but Arsenal prevented a full house of defeats for Premier League youngsters as they came from behind to win at AFC Wimbledon.
Zac Ashworth, Jerry Yates and Jordan Brown scored as Blackpool came from behind to defeat Villa 3-2 at Bloomfield Road.
The Villa youngsters took the lead when Fletcher Boyd netted in the 29th minute but the Seasiders came steaming back through Ashworth, Yates and Brown before Markie Meade pulled one back for Villa in stoppage time.
Blackpool are second in Northern Group B, while Villa remain rooted to the bottom of the group table, without a point.
Manchester City conceded four times in the first 34 minutes as they were humbled by Port Vale, who are next to bottom in League Two.
Maleace Asamoah scored the opener before Jaheim Headley, Max Watters, Lewis Montsma and Keyrol Figueroa completed the rout.
Vale top Northern Group D with seven points, while City are third.
Delighted Vale manager Jon Brady told BBC Radio Stoke: “It’s a competitive fixture and we attacked it with a strong team. We attacked it to win the game and I’m glad we scored five goals.”