The San Diego Padres (62-50) and the Arizona Diamondbacks (53-59) open a 3-game series Monday at Chase Field in Phoenix. First pitch is scheduled for 9:40 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s MLB odds around the Padres vs. Diamondbacks odds and make our expert MLB picks and predictions for the best bets.

Season series: Diamondbacks lead 4-3

The Padres secured the series win over the St. Louis Cardinals with a 7-3 victory on Sunday as heavy favorites (-185) as the Over (7.5) came in. San Diego led 7-0 after eight innings, and St. Louis posted 3 runs in the top of the ninth inning to save Over bettors, while handing Under bettors a bad beat.

San Diego OF Jackson Merrill went 1-for-3 with a triple, walk, run scored and 3 RBIs, while 2B Jake Cronenworth was 1-for-4 with a 2-run homer, with newcomer OF Ramon Laureano going 2-for-4 with a solo homer and 2 runs scored.

The Diamondbacks picked up 2 wins in 3 games in Sacramento against the A’s, winning each of the final 2 games as slight underdogs. The Under is 2-0-2 in the past 4 outings, while going 9-1-3 in the past 13 contests. Arizona 3B Blaze Alexander launched his first homer while finishing 2-for-5 with 2 RBIs. SS Geraldo Perdomo ended up 3-for-5 with a double, and OF Alek Thomas finished 3-for-4 with a run scored and an RBI.

The 2 wins for the Snakes halted a 6-game losing streak. Despite the victories, Arizona is still just 3-9 in the past 12 games since July 21.

Padres LHP JP Sears makes his team debut after being acquired from the A’s at the July 31 non-waiver trade deadline.

Padres at Diamondbacks projected starters

LHP JP Sears vs. RHP Brandon Pfaadt

Sears (7-9, 4.95 ERA) makes his 23rd start (first for Padres). He has a 1.27 WHIP, 2.4 BB/9 and 7.9 K/9 through 111 innings.

Last start (w/ A’s): Loss, 4 1/3 IP, 3 R (2 ER), 5 H (1 HR), 3 BB, 6 K in 3-1 home setback vs. Mariners July 282025 road stats: 4-4, 4.55 ERA (63 1/3 IP, 32 ER), 9 HR, 13 BB, 51 K, 1.17 WHIP in 12 startsCareer vs. Diamondbacks (1 startw/A’s): No-decision, 6 IP, 3 ER, 5 H (1 HR), 1 BB, 7 K in 9-4 road win June 28, 2024

Pfaadt (10-7, 5.11 ERA) makes his 23rd start. He has a 1.31 WHIP, 1.9 BB/9 and 7.6 K/9 through 116 1/3 innings.

Last start: Loss, 4 2/3 IP, 7 ER, 11 H (3 HR), 0 BB, 3 K in 12-2 road setback vs. Detroit Tigers last Tuesday2025 home stats: 6-3, 3.68 ERA (58 2/3 IP, 24 ER) 3 HR, 13 BB, 55 K, 1.28 WHIP in 11 starts2025 vs. Padres (July 9): Win, 8 IP, 2 ER, 4 H (1 HR), 0 BB, 4 K in 8-2 road victoryCareer vs. Padres: 2-2, 3.24 ERA (41 2/3 IP, 15 ER), 4 HR, 7 BB, 41 K 1.20 WHIP, 8.9 K/9 in 7 starts

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Padres at Diamondbacks odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:46 a.m. ET.

Moneyline (ML): Padres -145 (bet $145 to win $100) | Diamondbacks +120 (bet $100 to win $120)Run line (RL)/Against the spread (ATS): Padres -1.5 (+110) | Diamondbacks +1.5 (-135)Over/Under (O/U): 9.5 (O: +100 | U: -120)Padres at Diamondbacks picks and predictionsPrediction

Padres 5, Diamondbacks 2

PADRES (-145) is a strong play as moderate favorites in this series opener behind the southpaw Sears in his team debut.

The Diamondbacks (+120) took care of the A’s, but they’re still been playing poorly in the past 3 weeks, and Arizona was a big seller leading up to the deadline, with the offense a shell of its former self.

If you’re a little on the adventurous side, take PADRES -1.5 (+110) at plus-money behind the southpaw Sears.

The Diamondbacks are just 11-20 this season against left-handed starting pitchers, while the Padres are 42-33 against right-handed starting pitchers. Advantage San Diego.

UNDER 9.5 (-120) might be the best play on the board.

The Diamondbacks offense was gutted before the break, as 1B Josh Naylor and 3B Eugenio Suarez were shipped out. The Under is 9-1-3 in the past 13 games for Arizona, with the offense going for 3 or fewer runs in 10 of the past 12 outings.

For the Padres, the total has gone low in 3 of the past 5 games, while going 5-2 in the previous 7 contests on the road.

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