The Seattle Mariners (68-59) and Philadelphia Phillies (73-53) clash in a Wednesday matinee, as they close out a 3-game interleague series. The first pitch from Citizens Bank Park is slated for 1:05 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s MLB odds around the Mariners vs. Phillies odds and make our expert MLB picks and predictions for the best bets.

Season series: Philadelphia leads 2-0 with 12-7 and 6-4 wins

Seattle has dropped the first 2 games of this series — allowing a combined 18 runs along the way — and has lost 4 in a row. Since last Wednesday, the Mariners are 1-6 with a Boeing 7.02 ERA. The Mariners are 1 1/2 games behind the Houston Astros in the AL West and tied for the second Wild Card spot.

The NL East-leading Phillies, who have now won 4 straight home games against Seattle, have homered 7 times over the first 2 games of this series. Philadelphia has hit 25 round-trippers in going 8-3 at home since July 21.

Mariners at Phillies projected starters

RHP Luis Castillo vs. LHP Jesus Luzardo

Castillo (8-6, 3.48 ERA) is making his 26th start. He has a 1.22 WHIP, 2.4 BB/9 and 7.9 K/9 through 142 1/3 innings.

Last outing: No-decision, 4 IP, 6 ER, 9 H, 1 BB, 5 K in 11-9 win at New York Mets FridayCareer vs. Phillies: 1-1, 2.75 ERA (19 2/3 IP, 6 ER), 14 H, 3 BB, 21 K in 3 starts

Luzardo (11-6, 4.21 ERA) is making his 26th start. He owns a 1.34 WHIP, 3.1 BB/9 and 10.2 K/9 through 139 innings.

Last outing: Loss, 6 IP, 3 ER, 4 H, 3 BB, 7 K in 3-2 loss at Washington Nationals ThursdayCareer vs. Mariners: 2-1, 4.15 ERA (21 2/3 IP, 10 ER), 18 H, 4 BB, 27 K in 3 starts and 3 relief appearances

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Mariners at Phillies odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 7:53 a.m. ET.

Moneyline (ML): Mariners +118 (bet $100 to win $118) | Phillies -140 (bet $140 to win $100)Run line (RL)/Against the spread (ATS): Mariners +1.5 (-185) | Phillies -1.5 (+150)Over/Under (O/U): 8.5 (O: -115 | U: -105)Mariners at Phillies picks and predictionsPrediction

Phillies 4, Mariners 3

The Phillies are 5-2 across the last 7 series meetings.

Luzardo owns a 2.52 ERA, 0.92 WHIP over his last 4 starts. Overall this season, the Philadelphia lefty has been hurt by a .340 batting average on balls in play. Since the All-Star break , Seattle has clocked a subpar .675 OPS against left-handers.

Castillo owns a 4.92 ERA, 1.51 WHIP on the road. Per ESPN, current Philadelphia bats own an aggregate .983 OPS against him.

The Phillies bullpen has been a weakness this season, but that is not the case over recent weeks.

BET PHILADELPHIA (-140).

No interest. PASS.

Castillo registered a clunker in his last start, but he has a nice history of bouncing back in solid fashion. With Luzardo being a green-light candidate and the Seattle offense being on its back foot against a lefty starter, the UNDER 8.5 (-105) is a slight lean.

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