The San Francisco Giants (61-66) and San Diego Padres (71-56) will meet on Thursday at PETCO Park, starting at 4:10 p.m. ET.
The Padres are a home favorite (-139) against the Giants (+118). The Padres will start Dylan Cease (5-11) against the Giants and Justin Verlander (1-9).
These squads play again following the Padres’ 8-1 victory over the Giants yesterday. JP Sears (6.0 IP, 1 R, 4 H, 2 K) picked up the win for the Padres. Gavin Sheets went 2 for 4 with two home runs and four RBIs to lead the team on offense. Landen Roupp (2.1 IP, 5 R, 5 H, 2 K) was credited with the loss on the mound for the Giants.
Before this Padres vs. Giants matchup, here’s what you need to get ready for Thursday’s MLB action, including viewing options.
San Diego Padres vs. San Francisco Giants odds, line and spread
MLB odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 6:25 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Favorite: Padres (-139, bet $139 to win $100)Underdog: Giants (+118, bet $100 to win $118)Over/under: 8Padres vs. Giants: Game time and live stream infoGame day: Thursday, August 21, 2025Game time: 4:10 p.m. ETLocation: San Diego, CaliforniaStadium: PETCO ParkTV channel: SDPA and NBCS-BALive stream: Watch LIVE with Fubo! (Regional restrictions may apply)
Watch Padres vs. Giants on Fubo!
Padres stats and trendsPadres betting recordsThe Padres have entered the game as favorites 69 times this season and won 42, or 60.9%, of those games.San Diego has entered 43 games this season favored by -139 or more and is 27-16 in those contests.The moneyline for this contest implies a 58.2% chance of a victory for the Padres.San Diego and its opponents have hit the over in 52 of its 127 games with a total this season.The Padres have an ATS record of 71-56-0 in 127 games with a spread this season.Dylan Cease (Padres probable starter)Cease (5-11) gets the starting nod for the Padres in his 26th start of the season. He’s put together a 4.61 ERA in 132 2/3 innings pitched, with 171 strikeouts.His most recent appearance was on Sunday against the Los Angeles Dodgers, when the right-hander went 3 1/3 innings, surrendering three earned runs while allowing two hits.In 25 games this season, the 29-year-old has a 4.61 ERA and 11.6 strikeouts per nine innings, while allowing a batting average of .235 to his opponents.Cease is trying to record his eighth quality start of the year in this matchup.Cease has pitched five or more innings in a game 17 times this year heading into this game.He has had three appearances this season in which he kept his opponents to zero earned runs.He meets a Giants offense that ranks 25th in the league with 511 runs while batting .231 as a squad. It has a collective .374 slugging percentage (27th in MLB play) and has hit a total of 121 home runs (25th in MLB).In five innings over one appearance against the Giants this season, Cease has a 5.40 ERA and a 1.600 WHIP while his opponents are batting .263.The 29-year-old’s 4.61 ERA ranks 49th, 1.312 WHIP ranks 44th, and 11.6 K/9 ranks second among qualifying pitchers this season.Padres batting statsThe Padres’ 110 home runs rank second-to-last in MLB this season.The offense for San Diego has a slugging percentage of .385 this season, 25th in MLB.The Padres have a team batting average of .251 this season, which ranks eighth among MLB teams.San Diego has scored the 22nd-most runs in the majors this season with 531 (4.2 per game).The Padres are among the best in the league at getting on base, ranking eighth with an OBP of .322.San Diego has shown patience at the plate this season with the third-best rate of strikeouts per game (7.0) among MLB offenses.Giants stats and trendsGiants betting recordsThe Giants have been chosen as underdogs in 50 games this year and have walked away with the win 23 times (46%) in those games.This season, San Francisco has been victorious 10 times in 22 chances when named as an underdog of at least +118 or worse on the moneyline.The Giants have an implied victory probability of 45.9% according to the moneyline set by oddsmakers for this matchup.San Francisco and its opponents have gone over in 57 of its 127 games with a total set by sportsbooks this season.The Giants are 53-74-0 against the spread in their 127 games with a line set by sportsbooks this season.Justin Verlander (Giants probable starter)Verlander (1-9 with a 4.32 ERA and 95 strikeouts in 106 1/3 innings pitched) gets the start for the Giants, his 22nd of the season.In his most recent time out on Sunday, the righty tossed seven scoreless innings against the Tampa Bay Rays while surrendering two hits.The 42-year-old has an ERA of 4.32, with 8.0 strikeouts per nine innings in 21 games this season. Opponents are hitting .275 against him.Verlander is trying to pick up his eighth quality start of the season.Verlander is aiming for his sixth straight outing lasting five or more innings. He averages 5.1 innings per start.He has held his opponents without an earned run in three of his 21 appearances this season.He will take the hill against a Padres offense that ranks 15th in the league with 1067 total hits (on a .251 batting average). The team also slugs a collective .385 (25th in the league) with 110 total home runs (29th in MLB action).Giants batting statsThe Giants average 1.0 home run per game to rank 25th in MLB play with 121 total home runs.So far this year, San Francisco has the fourth-lowest slugging percentage in baseball (.374).The Giants are 28th in the majors with a .231 batting average.Averaging 4.0 runs per game (511 total), San Francisco is the 25th-highest scoring team in baseball.The Giants rank 22nd in MLB with an on-base percentage of .307.