At Chase Field on Friday, the Cincinnati Reds (67-61) open a three-game series against the Arizona Diamondbacks (62-66), at 9:40 p.m. ET.
The favored Diamondbacks (-134 moneyline odds to win) host the Reds (+114). The Arizona Diamondbacks will give the start to Ryne Nelson (6-3, 3.58 ERA), who is looking for win No. 7 on the season, and the Reds will turn to Zack Littell (9-8, 3.52 ERA).
The Diamondbacks were vicotrious 3-2 over the Guardians Wednesday in their most recent game. Lourdes Gurriel Jr. went 2 for 4 with a home run and two RBIs to lead them offensively while Andrew Saalfrank was earned the victory after throwing 2/3 of an inning without giving up a hit or an earned run while striking out one.
The Reds were handed a 2-1 loss to the Angels Wednesday. Ke’Bryan Hayes (2 for 3 with two doubles) led the way offensively, while Graham Ashcraft took the loss on the mound after going 2/3 of an inning, giving up one earned run on three hits.
Here is everything you need to prepare for Friday’s Diamondbacks vs. Reds contest, including viewing options.
Arizona Diamondbacks vs. Cincinnati Reds odds, line and spread
MLB odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 3:16 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Favorite: Diamondbacks (-134, bet $134 to win $100)Underdog: Reds (+114, bet $100 to win $114)Over/under: 8.5Diamondbacks vs. Reds: Game time and live stream infoGame day: Friday, August 22, 2025Game time: 9:40 p.m. ETLocation: Phoenix, ArizonaStadium: Chase FieldTV channel: ARID and FDSOHLive stream: Watch LIVE with Fubo! (Regional restrictions may apply)
Watch Diamondbacks vs. Reds on Fubo!
Diamondbacks stats and trendsDiamondbacks betting recordsThis season, the Diamondbacks have been favored 78 times and won 40, or 51.3%, of those games.Arizona has entered 48 games this season favored by -134 or more and is 24-24 in those contests.The Diamondbacks have a 57.3% chance to win this game based on the implied probability of the moneyline.Arizona’s games have gone over the total in 60 of its 127 chances.The Diamondbacks are 62-65-0 ATS in their 127 games with a spread this season.Ryne Nelson (Diamondbacks probable starter)Nelson gets the start for the Diamondbacks, his 17th of the season. He is 6-3 with a 3.58 ERA and 99 strikeouts in 113 2/3 innings pitched.His most recent time out came on Sunday against the Colorado Rockies, when the righty went 6 1/3 innings, surrendering four earned runs while giving up eight hits.In 26 games this season, the 27-year-old has put up a 3.58 ERA and 7.9 strikeouts per nine innings, while giving up a batting average of .215 to opposing batters.Nelson is trying to secure his sixth quality start of the season in this game.Nelson will look to last five or more innings for his seventh straight appearance. He’s averaging 4.3 frames per outing.In eight of his appearances this season he did not allow an earned run.The opposing Reds offense has a collective .248 batting average, and is 16th in the league with 1066 total hits and 11th in MLB action with 581 runs scored. It has the 21st-ranked slugging percentage (.392) and ranks 22nd in home runs (127) in all of MLB.Head-to-head against the Reds this season, Nelson has pitched three innings, giving up seven earned runs on four hits while striking out three.Diamondbacks batting statsThe Diamondbacks have hit 178 homers this season, which ranks fifth in the league.Fueled by 430 extra-base hits, Arizona ranks third in MLB with a .439 slugging percentage this season.The Diamondbacks’ .251 batting average is among the best in baseball, ranking eighth in MLB.Arizona is among the highest-scoring teams in the majors, ranking fifth with 628 total runs this season.The Diamondbacks have an OBP of .325 this season, which ranks sixth in MLB.Arizona is one of the most-disciplined teams at the plate this season, ranking 10th with an average of 7.9 strikeouts per game.Reds stats and trendsReds betting recordsThe Reds have been chosen as underdogs in 68 games this year and have walked away with the win 35 times (51.5%) in those games.Cincinnati has a win-loss record of 14-22 when favored by +114 or worse by sportsbooks this year.The Reds have an implied victory probability of 46.7% according to the moneyline set by sportsbooks for this matchup.Cincinnati and its opponents have gone over the total this season in 47 of its 125 opportunities.The Reds are 67-58-0 against the spread in their 125 games that had a posted line this season.Zack Littell (Reds probable starter)The Reds will send Littell (9-8) out for his 26th start of the season as he looks for his 10th win. He is 9-8 with a 3.52 ERA and 103 strikeouts through 151 2/3 innings pitched.The right-hander last appeared on Saturday against the Milwaukee Brewers, when he tossed six innings, allowing one earned run while giving up four hits.The 29-year-old has an ERA of 3.52, with 6.1 strikeouts per nine innings in 25 games this season. Opposing hitters have a .249 batting average against him.Littell is trying to collect his 16th quality start of the season in this matchup.Littell is looking to record his 24th start of five or more innings this season in this matchup.He has made one appearances this season in which he did not allow an earned run.The opposing Diamondbacks offense has the third-ranked slugging percentage (.439) and ranks fifth in home runs hit (178) in all of MLB. They have a collective .251 batting average, and are seventh in the league with 1086 total hits and fifth in MLB action scoring 628 runs.Littell has a 4.50 ERA and a 1.167 WHIP against the Diamondbacks this season in six innings pitched, allowing a .261 batting average over one appearance.Among pitchers who qualify in MLB play this season, the 29-year-old ranks 27th in ERA (3.52), 20th in WHIP (1.113), and 55th in K/9 (6.1).Reds batting statsThe Reds average 1.0 home run per game to rank 22nd in MLB action with 127 total home runs.So far this year, Cincinnati ranks 21st in baseball, slugging .392.The Reds have the 16th-ranked batting average in the league (.248).Averaging 4.5 runs per game (581 total), Cincinnati is the 11th-highest scoring team in baseball.The Reds are 14th in the majors with an on-base percentage of .318.