At Angel Stadium on Friday, the Chicago Cubs (73-55) begin a three-game series versus the Los Angeles Angels (61-66), at 9:38 p.m. ET.

The Cubs are a favorite (-146) at the Angels (+122). Tyler Anderson (2-8) will start for the Los Angeles Angels, but there’s been no pitching decision announced by the Chicago Cubs yet.

The Cubs lost 4-1 against the Brewers yesterday, with Shota Imanaga getting credited with the loss. He threw seven innings, giving up two earned runs on three hits while striking out five. Ian Happ went 1 for 2 to lead the Cubs offensively.

The Angels secured a 2-1 victory over the Reds Wednesday. Yoan Moncada (1 for 4 with a home run and an RBI) led the way offensively, while Reid Detmers got the win on the mound after going one inning without giving up a hit or an earned run while striking out two.

Prepare for the Cubs vs. Angels with what you need to know about Friday’s baseball action, including viewing options.

Chicago Cubs vs. Los Angeles Angels odds, line and spread

MLB odds courtesy of BetMGM Sportsbook. Odds updated Friday at 6:25 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Favorite: Cubs (-146, bet $146 to win $100)Underdog: Angels (+122, bet $100 to win $122)Over/under: 9.5Cubs vs. Angels: Game time and live stream infoGame day: Friday, August 22, 2025Game time: 9:38 p.m. ETLocation: Anaheim, CaliforniaStadium: Angel StadiumTV channel: FDSW and MARQLive stream: Watch LIVE with Fubo! (Regional restrictions may apply)

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Cubs stats and trendsCubs betting recordsThe Cubs have won 57, or 63.3%, of the 90 games they’ve played as favorites this season.Chicago is 39-15 this season when entering a game favored by -146 or more on the moneyline.The moneyline for this contest implies a 59.3% chance of a victory for the Cubs.Chicago and its opponents have gone over the total this season in 60 of 128 opportunities.In 128 games with a spread this season, the Cubs are 61-67-0 ATS.Cubs batting statsThe Cubs have hit 173 homers this season, which ranks seventh in the league.Fueled by 405 extra-base hits, Chicago ranks fifth in MLB with a .427 slugging percentage this season.The Cubs have a team batting average of .249 this season, which ranks 15th among MLB teams.Chicago has scored the fifth-most runs in the majors this season with 629.The Cubs have an OBP of .319 this season, which ranks 12th in MLB.Chicago ranks fourth in MLB in strikeouts per game with an average of 7.8 whiffs per contest.Angels stats and trendsAngels betting recordsThe Angels have been underdogs in 94 games this season and have come away with the win 44 times (46.8%) in those contests.Los Angeles has a win-loss record of 27-29 when favored by +122 or worse by oddsmakers this year.The Angels have an implied victory probability of 45% according to the moneyline set for this matchup.Los Angeles’ games have gone over the total in 69 of its 127 opportunities.The Angels have an against the spread record of 69-58-0 in 127 games with a line this season.Tyler Anderson (Angels probable starter)Anderson (2-8 with a 4.77 ERA and 98 strikeouts in 126 1/3 innings pitched) gets the start for the Angels, his 25th of the season.In his last time out on Sunday, the left-hander tossed four innings against the Athletics, giving up four earned runs while surrendering three hits.The 35-year-old has amassed an ERA of 4.77, with 7.0 strikeouts per nine innings in 24 games this season. Opposing batters have a .256 batting average against him.Anderson is looking to secure his seventh quality start of the season in this outing.Anderson has pitched five or more innings in a game 17 times this year entering this matchup.He has made three appearances this season in which he did not allow an earned run.The opposing Cubs offense has a collective .249 batting average, and is 10th in the league with 1085 total hits and fifth in MLB action with 629 runs scored. They have the fifth-ranked slugging percentage (.427) and are seventh in all of MLB with 173 home runs.Angels batting statsThe Angels rank fourth in MLB play with 179 home runs. They average 1.4 per game.So far this year, Los Angeles’ .407 slugging percentage is 12th in baseball.The Angels have the fifth-worst batting average in the league (.232).The offense for Los Angeles is the No. 16 offense in MLB, scoring 4.4 runs per game (558 total runs).The Angels are 24th in MLB with an on-base percentage of .306.

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