The Cleveland Guardians will take on the Tampa Bay Rays, in what is expected to be a close MLB game, at Progressive Field on Wednesday, commencing at 1:10PM ET.

The Guardians will have Slade Cecconi (5-6, 4.41 ERA) as their starting pitcher, pitting him against Drew Rasmussen (10-5, 2.62 ERA) for the Rays.

Based on updated simulation results, Dimers’ proven MLB model predicts the Rays as the most likely winner of today’s game.

“Our team has simulated the outcome of Wednesday’s Rays-Guardians game 10,000 times,” said Dimers’ Chief Content Officer, Nick Slade.

“With the latest updates and numerous other variables, we estimate the Rays’ chance of winning at 54%, with the Guardians at 46%.”

For further insights into Wednesday’s matchup, including best bets and picks, visit our interactive Rays vs. Guardians predictions page.

Guardians vs. Rays prediction: Who will win, cover the run line?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Wednesday’s MLB matchup between the Rays and Guardians 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Rays a 54% chance of beating the Guardians.

According to our model, the Guardians (+1.5) have a 59% chance of covering the run line, while the 7.5-run over/under has a 56% chance of going over.

 

Rays vs. Guardians odds [8/27/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type
Rays
Guardians

Run Line
-1.5 (+130)
+1.5 (-151)

Moneyline
-130
+114

Total
o7.5 (-114)
u7.5 (-106)

All odds are correct at the time of publication and are subject to change.

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Rays vs. Guardians picks and best bets

Our model’s strongest edge in today’s Rays vs. Guardians matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Calling Our Shot’s best bets

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Rays vs. Guardians game-day updates and essential details

Wednesday’s MLB game between the Guardians and Rays at Progressive Field is scheduled to commence at 1:10PM ET.

Dimers.com‘s full preview of Wednesday’s Rays vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any Rays vs. Guardians picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Rays, with a 54% win probability, will likely beat the Guardians on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Rays vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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