Angels at Padres Prediction: Odds, expert picks, starting pitchers, betting trends and stats for May 14

Its Wednesday, May 14 and the Angels (17-24) are in San Diego to take on the Padres (26-15). Kyle Hendricks is slated to take the mound for Los Angeles against Randy Vásquez for San Diego.

After a 6-4 loss last night, the Angels are now down in the series 2-0. Despite Dylan Cease’s stellar performance, Jason Adam picked up the win for the Padres after Jeremiah Estrada gave up two runs and blew the save.

Lets dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Angels at Padres

Date: Wednesday, May 14, 2025

Network/Streaming: Padres.TV, FanDuel Sports Network West

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Angels at the Padres

The latest odds as of Wednesday:

Moneyline: Angels (+156), Padres (-188)

Probable starting pitchers for Angels at Padres

Pitching matchup for May 14, 2025: Kyle Hendricks vs. Randy Vásquez

Angels: Kyle Hendricks, (1-4, 5.30 ERA)
Last outing (Baltimore Orioles, 5/9): 5.0 Innings Pitched, 3 Earned Runs Allowed, 6 Hits Allowed, 3 Walks, and 5 Strikeouts

Padres: Randy Vásquez, (2-3, 3.76 ERA)
Last outing (Colorado Rockies, 5/9): 6.0 Innings Pitched, 2 Earned Runs Allowed, 6 Hits Allowed, 1 Walks, and 5 Strikeouts

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Top betting trends & insights to know ahead of Angels at Padres

The Padres are showing a 129% return on investment at home on the Money Line

5 of the Angels’ last 6 road trips to the Padres have gone over the Total

The Angels are 5-5 in their last 10 road games

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for tonight’s game between the Angels and the PadresRotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Wednesday’s game between the Angels and the Padres:

Moneyline: NBC Sports Bet is recommending a play on the San Diego Padres on the Moneyline.

Spread: NBC Sports Bet is leaning towards a play ATS on the Los Angeles Angels at +1.5.

Total: NBC Sports Bet is leaning towards a play on the over on the Game Total of 8.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

Follow our experts on socials to keep up with all the latest content from the staff:

Jay Croucher (@croucherJD)

Drew Dinsick (@whale_capper)

Vaughn Dalzell (@VmoneySports)

Brad Thomas (@MrBradThomas)

Angels at Padres Prediction: Odds, expert picks, starting pitchers, betting trends and stats for May 14

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