A series opener between the Cincinnati Reds (21-24) and Cleveland Guardians (25-18) is scheduled for Friday at 6:40 p.m. ET, at Great American Ball Park.

As the favorite, the Guardians (-123 moneyline odds) visit the Reds (+103). The Guardians will start Tanner Bibee (3-3) against the Reds and Brady Singer (4-2).

The Guardians lost their most recent game against the Brewers by a 9-5 score Wednesday. Jose Ramirez went 1 for 3 with a home run and three RBIs to lead them offensively. Tim Herrin picked up the loss after throwing 1/3 of an inning, giving up two earned runs on one hit while striking out one.

The Reds earned a 7-1 victory against the White Sox yesterday. Matt McLain (2 for 3 with a double, a home run and an RBI) led the way offensively, while Nicholas Martinez got the win on the mound after going seven innings without giving up an earned run on two hits, while striking out three.

Ahead of this Guardians vs. Reds showdown, here is everything you need to prepare for Friday’s MLB action, including viewing options.

Cleveland Guardians vs. Cincinnati Reds odds, line and spread

MLB odds courtesy of BetMGM Sportsbook. Odds updated Friday at 12:16 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Favorite: Guardians (-123, bet $123 to win $100)Underdog: Reds (+103, bet $100 to win $103)Over/under: 9Guardians vs. Reds: Game time and live stream infoGame day: Friday, May 16, 2025Game time: 6:40 p.m. ETLocation: Cincinnati, OhioStadium: Great American Ball ParkTV channel: FDSOH and CLEGLive stream: Watch LIVE with Fubo! (Regional restrictions may apply)

Watch Guardians vs. Reds on Fubo!

Guardians stats and trendsGuardians betting recordsThe Guardians have been favorites in 17 games this season and won 12 (70.6%) of those contests.Cleveland has a record of 8-2, a 80% win rate, when favored by -123 or more by oddsmakers this season.The Guardians have a 55.2% chance to win this game based on the implied probability of the moneyline.Cleveland and its opponents have hit the over in 20 of its 42 games with a total this season.The Guardians are 19-23-0 against the spread this season.Tanner Bibee (Guardians probable starter)The Guardians are sending Bibee (3-3) out to make his ninth start of the season. He is 3-3 with a 3.80 ERA and 31 strikeouts through 45 2/3 innings pitched.In his most recent appearance on Saturday against the Philadelphia Phillies, the right-hander threw seven innings, allowing one earned run while surrendering five hits.In eight games this season, the 26-year-old has put up a 3.80 ERA and 6.2 strikeouts per nine innings, while allowing a batting average of .229 to his opponents.Bibee is looking to record his fourth quality start of the year in this outing.Bibee will try to pitch five or more innings for his sixth straight appearance. He’s averaging 5.6 innings per outing.In two of his appearances this season he did not allow an earned run.He will face a Reds offense that ranks 14th in MLB with 362 total hits (on a .239 batting average). The squad also slugs a collective .385 (14th in MLB) with 47 total home runs (13th in MLB).The 26-year-old’s 3.80 ERA ranks 53rd, 1.200 WHIP ranks 43rd, and 6.2 K/9 ranks 72nd among qualifying pitchers this season.Guardians batting statsThe Guardians have hit 48 homers this season, which ranks 12th in the league.Hitters for Cleveland have combined for a team rank of 19th in the majors with a .381 team slugging percentage.The Guardians have a team batting average of .233 this season, which ranks 23rd among MLB teams.Cleveland has scored 176 runs (4.1 per game) this season, which ranks 18th in MLB.The Guardians have an OBP of .308 this season, which ranks 22nd in MLB.Cleveland has shown patience at the plate this season with the ninth-best rate of strikeouts per game (7.9) among MLB offenses.Reds stats and trendsReds betting recordsThe Reds have won in 10, or 43.5%, of the 23 contests they have been named as odds-on underdogs this year.This season, Cincinnati has been victorious seven times in 17 chances when named as an underdog of at least +103 or worse on the moneyline.The moneyline set for this matchup implies the Reds have a 49.3% chance of walking away with the win.Contests with Cincinnati has gone over the total set by sportsbooks in 18 of 45 chances this season.The Reds are 23-22-0 against the spread in their 45 games with a line set by sportsbooks this season.Brady Singer (Reds probable starter)Singer makes the start for the Reds, his ninth of the season. He is 4-2 with a 4.97 ERA and 39 strikeouts in 41 2/3 innings pitched.The right-hander’s last appearance was on Saturday against the Houston Astros, when he went 2 1/3 innings, surrendering seven earned runs while giving up nine hits.The 28-year-old has amassed a 4.97 ERA and 8.4 strikeouts per nine innings across eight games this season, while allowing a batting average of .248 to opposing batters.Singer is trying to collect his fourth quality start of the year.Singer will try to record his seventh outing of five or more innings pitched this season. He averages 5.2 innings per appearance.He has had one appearances this season in which he did not allow an earned run.He will face a Guardians team that is hitting .233 as a unit (23rd in the MLB). They are also slugging a collective .381 (19th in the league) with 48 total home runs (12th in MLB play).Reds batting statsThe Reds rank 13th in MLB play with 47 total home runs.So far this year, Cincinnati is 14th in baseball, slugging .385.The Reds have the 18th-ranked batting average in the majors (.239).Cincinnati is the ninth-highest scoring team in baseball, averaging 4.6 runs per game (208 total).The Reds rank 14th in the majors with an on-base percentage of .319.

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