At Rate Field on Friday, the Chicago White Sox (57-96) open a three-game series versus the San Diego Padres (83-70), at 7:40 p.m. ET.
The White Sox play as a home underdog (+141) versus the Padres (-169). The Padres will start Dylan Cease (8-11) against the White Sox and Davis Martin (6-10).
The Padres lost 6-1 against the Mets yesterday, with Randy Vasquez getting credited with the loss. He threw 2 1/3 innings, giving up four earned runs on four hits while striking out three. Fernando Tatis Jr. went 2 for 4 to lead the Padres offensively.
The White Sox were defeated by the Orioles 3-1 Wednesday. Mike Tauchman led the way offensively after going 1 for 3 with a home run and an RBI in the defeat, while Martin Perez took the loss on the mound, throwing 3 2/3 innings, giving up three earned runs on five hits while striking out two.
Before watching this Padres vs. White Sox matchup, here is what you need to know about Friday’s action on the diamond, including viewing options.
San Diego Padres vs. Chicago White Sox odds, line and spread
MLB odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 9:16 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Favorite: Padres (-169, bet $169 to win $100)Underdog: White Sox (+141, bet $100 to win $141)Over/under: 8Padres vs. White Sox: Game time and live stream infoGame day: Friday, September 19, 2025Game time: 7:40 p.m. ETLocation: Chicago, IllinoisStadium: Rate FieldTV channel: CHSN and SDPALive stream: Watch LIVE with Fubo! (Regional restrictions may apply)
Watch Padres vs. White Sox on Fubo!
Padres stats and trendsPadres betting recordsThe Padres have been favorites in 85 games this season and won 50 (58.8%) of those contests.This season San Diego has won 19 of its 31 games, or 61.3%, when favored by at least -169 on the moneyline.The Padres have a 62.8% chance to win this game based on the implied probability of the moneyline.Games involving San Diego have gone over the total set by bookmakers in 65 of 153 chances this season.The Padres are 82-71-0 ATS in their 153 games with a spread this season.Dylan Cease (Padres probable starter)Cease (8-11 with a 4.59 ERA and 201 strikeouts in 157 2/3 innings pitched) gets the start for the Padres, his 31st of the season.The righty last appeared on Sunday against the Colorado Rockies, when he went six innings, allowing one earned run while giving up five hits.In 30 games this season, the 29-year-old has a 4.59 ERA and 11.5 strikeouts per nine innings, while allowing a batting average of .238 to his opponents.Cease is trying to secure his ninth quality start of the year in this matchup.Cease will try to prolong a three-game streak of going five or more innings (he’s averaging 5.2 frames per outing).He has made three appearances this season in which he did not surrender an earned run.The opposing White Sox offense has the 28th-ranked slugging percentage (.373) and is 22nd in MLB play with 154 home runs. It has a collective .233 batting average, and is 27th in MLB with 1184 total hits and 26th in MLB action scoring 609 runs.Among qualifying pitchers in MLB play this season, the 29-year-old ranks 42nd in ERA (4.59), 41st in WHIP (1.325), and first in K/9 (11.5).Padres batting statsThe Padres’ 140 home runs rank second-to-last in MLB this season.Hitters for San Diego have combined for a team rank of 23rd in the majors with a .389 team slugging percentage.The Padres rank seventh in MLB with a .252 team batting average.San Diego ranks 21st in the majors with 652 total runs scored this season.The Padres have an OBP of .321 this season, which ranks 10th in MLB.San Diego has shown patience at the plate this season with the third-best rate of strikeouts per game (7.1) among MLB offenses.White Sox stats and trendsWhite Sox betting recordsThe White Sox have been chosen as underdogs in 150 games this year and have walked away with the win 56 times (37.3%) in those games.Chicago has a win-loss record of 25-55 when favored by +141 or worse by sportsbooks this year.The White Sox have an implied victory probability of 41.5% according to the moneyline set by oddsmakers for this matchup.Chicago and its opponents have gone over in 69 of its 153 games with a total set by sportsbooks this season.The White Sox have an against the spread mark of 89-64-0 in 153 games with a line this season.Davis Martin (White Sox probable starter)Martin (6-10 with a 4.01 ERA and 95 strikeouts in 132 1/3 innings pitched) gets the start for the White Sox, his 24th of the season.His last appearance came on Saturday against the Cleveland Guardians, when the right-hander went five innings, surrendering two earned runs while giving up five hits.In 24 games this season, the 28-year-old has amassed an ERA of 4.01, with 6.5 strikeouts per nine innings. Opponents are batting .249 against him.Martin is trying to pick up his ninth quality start of the year in this game.Martin will aim to last five or more innings for his fourth straight start. He’s averaging 5.5 innings per outing.In four of his appearances this season he has not surrender an earned run.He will face off against a Padres squad that is batting .252 as a unit (seventh in the MLB). They are also slugging a collective .389 (23rd in the league) with 140 total home runs (29th in MLB action).White Sox batting statsThe White Sox average one home run per game to rank 22nd in MLB play with 154 total home runs.So far this year, Chicago is slugging .373, the third-lowest percentage in the majors.The White Sox rank 27th in the majors with a .233 batting average.Chicago scores the fifth-fewest runs in baseball (609 total, four per game).The White Sox rank 27th in MLB with a .302 on-base percentage.