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Shohei Ohtani gets the nod for the Los Angeles Dodgers on Tuesday at Chase Field against Geraldo Perdomo and the Arizona Diamondbacks. First pitch is at 9:40 p.m. ET for the first game of a three-game series. The Dodgers are listed as -176 moneyline favorites in this matchup against the Diamondbacks (+148). Los Angeles is the run-line favorite (-1.5). The over/under is 9 runs for the matchup.
Here’s everything you need from a betting perspective on the Dodgers-Diamondbacks game, regarding the run line, moneyline and total, plus expert picks.
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Dodgers vs Orioles Highlights | MLB on FOX 
Check out the best highlights between the Los Angeles Dodgers and the Baltimore Orioles.
Dodgers vs. Diamondbacks Game Information & OddsWhen: Tuesday, September 23, 2025 at 9:40 p.m. ETWhere: Chase Field in Phoenix, ArizonaHow to watch on TV: ARID and SportsNet LA Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds Run Line Favorite Run Line Odds Underdog Run Line Odds Dodgers -176 +148 9 +100 -122 -1.5 -104 -115 Dodgers vs. Diamondbacks PredictionScore Prediction: Diamondbacks 6, Dodgers 5Total Prediction: Over 9 runsWin Probabilities: Dodgers 51%, Diamondbacks 49%Dodgers vs. Diamondbacks Betting InsightsThis season, the Dodgers have won 79 out of the 138 games, or 57.2%, in which they’ve been favored.Los Angeles has a record of 47-28 in games when sportsbooks favor them by at least -176 on the moneyline.The sportsbooks’ moneyline implies a 63.8% chance of a victory for the Dodgers.The Diamondbacks have come away with 33 wins in the 66 contests they have been listed as the underdogs in this season.Arizona has a win-loss record of 2-4 when favored by +148 or worse by sportsbooks this year.The Diamondbacks have an implied victory probability of 40.3% according to the moneyline set by oddsmakers for this matchup.Dodgers Recent Betting PerformanceThe Dodgers have a 5-4 record from the nine games they were favored on the moneyline over their last 10 matchups.In their last 10 outings, the Dodgers and their opponents combined to go over the run total five times (all 10 of the games had set totals).The Dodgers are 6-4-0 against the spread over their past 10 games.Dodgers Recent Stats Stat Avg/Total Record 6-4 Runs Per Game 5.6 HR 17 ERA 3.85 K/9 10.8 Dodgers Player InsightsThe Dodgers’ best power option comes in the form of Ohtani and his 53-homer 99-RBI season, both team highs.In all of MLB, Ohtani ranks second in home runs and 13th in RBI.Ohtani takes a hitting streak of nine games into this game. In his last 10 outings he is hitting .325 with three doubles, five home runs, eight walks and seven RBIs.Mookie Betts is hitting .258 with 23 doubles, two triples, 20 home runs and 60 walks.Betts ranks 76th in home runs and 52nd in RBI among all hitters in baseball.Freddie Freeman has accumulated a team-high batting average of .292.Freeman will look to build on his two-game hitting in this game. In his last five games he is batting .250 with a home run and three RBIs.Andy Pages is batting .278 with 27 doubles, a triple, 25 home runs and 28 walks.Diamondbacks Recent Betting PerformanceIn five games as underdogs over the last 10 matchups, the Diamondbacks have a record of 4-1.In their last 10 games with a total, the Diamondbacks and their opponents are 5-4-1 when it comes to hitting the over.The Diamondbacks have won seven of their last 10 games against the spread.Diamondbacks Recent Stats Stat Avg/Total Record 7-3 Runs Per Game 5.4 HR 11 ERA 3.71 K/9 7.7 Diamondbacks Player InsightsPerdomo has posted a team-best batting average of .290 and paces the Diamondbacks in runs batted in with a mark of 97.In all of the big leagues, Perdomo ranks 86th in homers and 14th in RBI.Perdomo brings a hitting streak of 11 games into this game. During his last 10 outings he is batting .405 with four doubles, a triple, two home runs, seven walks and six RBIs.Corbin Carroll has shown his power as he paces his team with 31 home runs.Among all MLB batters, Carroll ranks 15th in home runs and 33rd in RBI.Ketel Marte is hitting .280 with 26 doubles, 26 home runs and 63 walks.Gabriel Moreno has 12 doubles, a triple, nine home runs and 25 walks while batting .291.Dodgers vs Orioles Highlights | MLB on FOX
Check out the best highlights between the Los Angeles Dodgers and the Baltimore Orioles.
FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.
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