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Logan Webb takes the mound for the San Francisco Giants on Tuesday at Oracle Park against Ivan Herrera and the St. Louis Cardinals. First pitch is at 9:45 p.m. ET. The Giants are favored in this one, at -198, while the underdog Cardinals have +164 odds to win. San Francisco is a 1.5-run favorite (at +113 odds). The over/under is 7.5 runs for the contest (with -109 odds to go over and -111 odds on the under).
Check out everything you need to know from a betting perspective on the Giants-Cardinals game, regarding the run line, moneyline and total, plus expert picks.
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Giants vs. Cardinals Game Information & OddsWhen: Tuesday, September 23, 2025 at 9:45 p.m. ETWhere: Oracle Park in San Francisco, CaliforniaHow to watch on TV: NBCS-BA and FDSMW Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds Run Line Favorite Run Line Odds Underdog Run Line Odds Giants -198 +164 7.5 -109 -111 -1.5 +113 -134 Giants vs. Cardinals PredictionScore Prediction: Giants 5, Cardinals 4Total Prediction: Over 7.5 runsWin Probabilities: Giants 55%, Cardinals 45%Giants vs. Cardinals Betting InsightsThe Giants have entered the game as favorites 87 times this season and won 46, or 52.9%, of those games.San Francisco has a record of 6-5, a 54.5% win rate, when favored by -198 or more by bookmakers this season.The implied probability of a win from the Giants, based on the moneyline, is 66.4%.The Cardinals have come away with 42 wins in the 88 contests they have been listed as the underdogs in this season.This year, St. Louis has won two of nine games when listed as at least +164 or worse on the moneyline.The moneyline set for this matchup implies the Cardinals have a 37.9% chance of walking away with the win.Giants Recent Betting PerformanceThe Giants were listed as the moneyline favorite by oddsmakers only once over the last 10 games, and lost that matchup.Over their last 10 matchups, the Giants and their opponents combined to go over the total four times (all 10 games had set totals).The Giants have put together a 5-5-0 record against the spread over their past 10 games.Giants Recent Stats Stat Avg/Total Record 3-7 Runs Per Game 3.7 HR 5 ERA 5.22 K/9 6.3 Giants Player InsightsRafael Devers has a team-best 32 home runs and 105 runs batted in.Of all hitters in MLB, Devers’ home run total places him 14th, and his RBI tally puts him eighth.Devers brings a hitting streak of two games into this game. In his last five games he is batting .150 with a home run, three walks and three RBIs.Jung Hoo Lee has a club-leading .261 batting average.Lee is 243rd in home runs and 149th in RBI in the majors.Willy Adames is batting .226 with 21 doubles, two triples, 28 home runs and 79 walks.Heliot Ramos is batting .256 with 24 doubles, a triple, 18 home runs and 51 walks.Cardinals Recent Betting PerformanceThe Cardinals have played as underdogs in nine of their past 10 games and won four of those contests.The Cardinals and their opponents have combined to hit the over four times in their last 10 games with a total.The Cardinals have six wins against the spread in their last 10 chances.Cardinals Recent Stats Stat Avg/Total Record 4-6 Runs Per Game 4.0 HR 6 ERA 3.48 K/9 8.3 Cardinals Player InsightsAlec Burleson paces the Cardinals with a team-leading batting average of .289.Among all hitters in the majors, Burleson’s home run total is 97th and his RBI tally is 94th.Burleson takes a hitting streak of six games into this game. In his last 10 outings he is batting .333 with three doubles, a triple, a home run, four walks and four RBIs.Brendan Donovan has 27 doubles, 10 home runs and 42 walks while hitting .282.Donovan is currently 207th in home runs and 181st in RBI in the big leagues.Lars Nootbaar is batting .236 with 23 doubles, a triple, 13 home runs and 59 walks.Herrera is hitting .281 with 13 doubles, 17 home runs and 39 walks.Giants vs. Cardinals Highlights | MLB on FOX 
Check out the best highlights between the St. Louis Cardinals and San Francisco Giants.
FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.
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