The Houston Astros will visit the Athletics in Sacramento on Wednesday night. The Astros have reached a critical point in their season as they have gone from AL West leaders to outside of the Wild Card spots in the American League. They have to win games like this one to get back into the playoff picture. Before Houston tries to do that at the expense of the A’s, you can continue reading to get my Astros vs Athletics prediction for tonight.
Our Astros vs Athletics PickPick: Houston Astros -1.5Confidence: ★★★★☆Game SnapshotMatchup: Houston Astros vs AthleticsDate & Time: Wednesday, September 24, 2025, 10:05 PM ETStarting Pitchers: Hunter Brown (HOU) vs. Luis Severino (ATH)Stadium: Sutter Health Park, West Sacramento, CABroadcast: NBCS-CA, Space City Home NetworkKey StorylinesPitching Matchup
Hunter Brown (12-8, 2.30 ERA) takes the mound for the Astros. He is a dominant presence on the mound and he is just the pitcher that the Astros would want to start in a game this important. His impressive ERA and high strikeout rate make him a difficult for any team to deal with, especially a struggling team like the Athletics. Luis Severino (7-11, 4.72 ERA) starts for the A’s in this contest. While Severino has had some strong outings, his inconsistency this season presents an opportunity for the Astros to capitalize upon.
Key PlayersJose Altuve (HOU): Despite some recent struggles, Altuve remains a key figure in Houston’s lineup and will be crucial in setting the tone offensively.Nick Kurtz (ATH): Leading the Athletics with 33 home runs, Kurtz poses a significant threat to the Astros’ pitching staff.Hunter Brown (HOU): As the starting pitcher, Brown’s performance will be so important in setting up the Astros for success tonight.Recent Team Streaks
The Astros are currently on a four-game losing streak, placing additional pressure on them to perform here. The Athletics played with heart late in the season, securing a 5-1 victory in the series opener. They are 3-2 over their last five games.
Best Player PropsPlayerPropHunter BrownOver 7.5 StrikeoutsNick Kurtz1+ Home RunJose AltuveOver 0.5 RBIsBetting Trends & H2HThe A’s lead their season series with the Astros by a margin of 7-4.With their win on Tuesday night, the A’s clinched the season series against the Astros for the 2025 season.Every game between these teams has been decided by two runs or more.Astros vs Athletics Model ProjectionScore Projection: Astros 6 – Athletics 3Win Probability: Astros 65%, Athletics 35%Final Thoughts
There has not been a one-run game between the A’s and Astros this season despite there being 11 games played between them. I expect that trend to continue tonight, as the winner of this game will likely get the win by two runs or more. I think that team will be the Astros, thanks to the superior starting pitching of Hunter Brown.
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