The Miami Marlins (77-80) and the Philadelphia Phillies (92-65) play the middle contest of a 3-game series Wednesday at Citizens Bank Park in Philadelphia, Pennsylvania. First pitch is scheduled for 6:45 p.m. ET. Let’s analyze BetMGM Sportsbook’s MLB odds around the Marlins vs. Phillies odds and make our expert MLB picks and predictions for the best bets.

Season series: Phillies lead 7-4

The Marlins picked up a 6-5 win in 11 innings Tuesday in the series opener, cashing as huge underdogs (+185) as the Over (7.5) came through. Philadelphia took a 3-0 lead through the first 2 innings, but Miami scored 2 runs in the final 2 frames to force extra innings. The Marlins scored 3 in extras, while the Phillies scored 2, coming up just short.

Miami DH Heriberto Hernandez finished 3-for-5 with a double and a solo homer, while C Liam Hicks ended up 2-for-2 with an RBI, coming off the bench in the middle of the game. Miami has won 7 in a row, and 11 of the past 12 games, while the Over is 5-2 in the past 7 games and 10-4 in the past 14 outings.

In Tuesday’s loss, the Phillies saw DH Kyle Schwarber sock his 54th homer, a solo shot, while 1B Otto Kemp went 1-for-4 with a homer and 2 RBIs.

Philadelphia slipped to 92-65 with a third straight loss, and it is 2½ games back of the Milwaukee Brewers for the top overall seed in the National League with 5 games remaining.

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Marlins at Phillies projected starters

LHP Ryan Weathers vs. LHP Jesus Luzardo

Weathers (2-1, 3.21 ERA) makes his eighth start. He has a 1.22 WHIP, 2.7 BB/9 and 7.8 K/9 through 33 2/3 innings.

Last start: No-decision, 4 IP, 3 ER, 8 H, 2 BB, 2 K in 8-4 victory at Colorado Rockies Sept. 172025 road stats: 1-0, 3.57 ERA (17 2/3 IP, 7 ER), 1.30 WHIP, 2 HR, 7 BB, 14 K in 4 startsCareer vs. Phillies: 0-2, 9.45 ERA (6 2/3 IP, 7 ER), 1.95 WHIP, 3 HR, 2 BB, 4 K in 1 start and 1 relief appearance

Luzardo (14-7, 4.08 ERA) makes his 32nd start. He has a 1.25 WHIP, 2.9 BB/9 and 10.5 K/9 through 176 2/3 innings.

Last start: Loss, 7 IP, 4 ER, 6 H (2 HR), 1 BB, 6 K in 5-0 defeat at LA Dodgers Sept. 17Last 7 starts: 3-2, 3.71 ERA (43 2/3 IP, 18 ER), 0.96 WHIP, 11.3 K/92025 home stats: 7-2, 4.50 ERA (86 IP, 43 ER), 1.17 WHIP, 8 HR, 11.1 K/9 in 15 startsCareer vs. Marlins: 1-1, 3.50 ERA (18 IP, 7 ER), 1 HR, 8 BB, 19 K in 3 starts in 2025Marlins at Phillies odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:20 a.m. ET.

Moneyline (ML): Marlins +165 (bet $100 to win $165) | Phillies -200 (bet $200 to win $100)Run line (RL)/Against the spread (ATS): Marlins +1.5 (-130) | Phillies -1.5 (+110)Over/Under (O/U): 7.5 (O: -110 | U: -110)

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Marlins at Phillies picks and predictionsPrediction

Phillies 4, Marlins 3

The Phillies (-200) will cost you 2 times your potential return, and that’s way too much risk for not enough reward on a singular bet.

As far as a parlay — or perhaps using a boost or promo — that makes a Philadelphia play a little more manageable.

PASS, and look to the run line instead.

If you don’t trust the underdogs, but you want some insurance, MARLINS +1.5 (-130) is a solid play.

Miami has been on fire lately, and really, a Weathers-Luzardo pitching matchup is rather neutral. The difference here, or at least it should be, is venue. Of course, that didn’t matter much in Tuesday’s win by the visitors.

UNDER 7.5 (-110) is the lean, but go with a half-unit play at best.

We had an Over result Tuesday, but the Under has a slight 2-1 edge in the past 3 games. For Weathers, the Under has a 4-3 edge in 7 starts for the Miami southpaw.

For the Phillies, while the Over is 11-2 in the past 13 games, the Under has cashed 3 times in the past 4 starts by Luzardo.

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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