The Minnesota Twins (25-20) and the Milwaukee Brewers (21-24) play the middle contest of a 3-game interleague series Saturday at American Family Field. First pitch is scheduled for 7:15 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s MLB odds around the Twins vs. Brewers odds and make our expert MLB picks and predictions for the best bets.

Season series: Twins lead 1-0

The Twins picked up a 3-0 road victory in Friday’s interleague series opener at American Family Field in Milwaukee behind RHP Joe Ryan, who twirled 6 scoreless frames with 9 strikeouts to move to 4-2 while lowering his ERA to 2.42. C Christian Vazquez had a pair of hits, including a double, in 4 at-bats. 1B Ty France went 1-for-4 with an RBI single Friday, bringing his season total to 22 RBIs.

The Brewers received a quality start from RHP Chad Patrick, who allowed 3 runs while scattering 8 hits across 6 innings on 88 pitches. 2B Brice Turang led off with a single and 2 steals across 4 at-bats, while C William Contreras had a single and double in 4 at-bats.

Minnesota has won 12 games in a row since May 3, including a pair of shutout victories on the road. It has cashed the Under in each of the past 2 outings, while going 6-3 in the previous 9 contests.

Milwaukee is 1-3 in the past 4 outings, and all 3 of the setbacks were via shutout. The Brewers are just 2-6 in the past 8 outings since May 7, while the Under has hit in 10 of the past 12 contests since May 3. Milwaukee has been blanked in 5 of the past 14 games, going just 5-9 in the span.

Twins at Brewers projected starters

RHP Pablo Lopez vs. RHP Tobias Myers

Lopez (3-2, 2.77 ERA) makes his eighth start. He has a 0.97 WHIP, 1.6 BB/9 and 10.0 K/9 in 39 innings.

Last start: No-decision, 6 IP, 4 ER, 5 H (1 HR), 2 BB, 6 K in 7-6 home victory in 10 innings vs. San Francisco Giants Sunday2025 road splits: 1-2, 1.96 ERA (23 IP, 5 ER), 2 HR, 2 BB, 20 K, 0.91 WHIP in 4 starts2024 vs. Brewers (1 start): No-decision, 7 IP, 1 ER, 4 H, 1 BB, 7 K in 8-4 home defeat in 12 innings July 20Career vs. Brewers: 1-1, 3.07 ERA (44 IP, 15 ER), 3 HR, 13 BB, 49 K, 0.91 WHIP in 7 starts

Myers (1-0, 3.86 ERA) makes his fifth start and sixth appearance. He has a 1.53 WHIP, 5.5 BB/9, 6.1 K/9 in 16 1/3 innings.

Last start: No-decision, 4 IP, 2 ER, 3 H, 3 BB, 3 K in 3-2 road loss vs. Tampa Bay Rays last Saturday (May 10)2025 home split: 1-0, 1.42 ERA (6 1/3 IP, 1 ER), 0 BB, 3 K, 0.95 WHIP in 1 start and 1 relief appearanceHas never faced Twins

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Twins at Brewers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:45 a.m. ET.

Moneyline (ML): Twins -115 (bet $115 to win $100) | Brewers -105 (bet $105 to win $100)Run line (RL)/Against the spread (ATS): Twins -1.5 (+150) | Brewers +1.5 (-185)Over/Under (O/U): 7.5 (O: -115 | U: -105)Twins at Brewers picks and predictionsPrediction

Twins 5, Brewers 2

The TWINS (-115) are a strong play in the middle contest of this 3-game interleague series, as Minnesota looks to stay red hot.

Minnesota has won 12 in a row, while Milwaukee has dropped 3 of the past 4 outings, all via shutout, and the Brewers are just 2-6 across the past 8 games.

The TWINS -1.5 (+150) are a decent play at plus-money if you’re a little less conservative. Minnesota has not only won 12 straight contests, but it has picked up victories by 2 or more runs in 4 straight contests, with an average of 3.0 runs per game during the span. Minnesota is also 4-1 on the run line as a favorite in the past 5 tries since May 6.

As an underdog, the Brewers are a respectable 9-5 in the past 14 games on the run line. Back the red-hot Twins to get the job done by at least 2 runs.

UNDER 7.5 (-105) is the lean, so go with a half-unit play at best.

The Under is 6-1 in the past 7 games for the ice-cold Brewers, scoring 3 or fewer runs in 6 of the past 8 outings. Milwaukee is an Under machine lately, going 10-2 in the past 12 games since May 3, too.

For Minnesota, the Under has hit in the past 2 games, both shutout victories, while going 6-3 in the past 9 contests, while hitting at a 13-6 clip in the previous 19 games.

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