The Cleveland Guardians and Carlos Santana will hit the field against the Cincinnati Reds and TJ Friedl on Saturday at 6:40 p.m. ET, at Great American Ball Park.

The pitching staff for the Guardians has a collective 8.5 K/9, which ranks 13th in the majors. The Reds have a team batting average of .241 this season, which ranks 17th among MLB teams.

Get ready for the Guardians vs. Reds with everything you need to know about Saturday’s game, including viewing options.

Guardians vs. Reds: live stream info, TV channel & game timeGame day: Saturday, May 17, 2025Game time: 6:40 p.m. ETLocation: Cincinnati, OhioStadium: Great American Ball ParkTV channel: FanDuel Sports Network IndianaLive stream: Watch LIVE with Fubo! (Regional restrictions may apply)

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Guardians vs. Reds odds & betting linesFavorite: Guardians (-126, bet $126 to win $100)Underdog: Reds (+106, bet $100 to win $106)Over/under: 9.5

MLB odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 9:07 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.