The Chicago Cubs are set to host the St. Louis Cardinals to open the pivotal three-game series on September 26, 2025, at 2:20 pm ET/11:20 am PT.
Chicago is eighth with an average of 4.86 runs per game, while the Cardinals are in 18th place with an average of 4.31 runs per game. Additionally, St. Louis is rated 17th with a hitting average of .246, while the Cubs are slightly ahead at 14th place with an average of .249.
Chicago leads in on-base percentage as well, ranking 11th with .320, while the Cardinals are not far behind at 14th with .316. The Cubs are ranked seventh with a slugging percentage of.427, while the Cardinals are placed 27th with a slugging percentage of .380.
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How to watch Chicago Cubs vs St. Louis Cardinals on TV & stream live online
National TV channel: MLBN
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TeamLocal NetworkStreaming ProvidersArizona DiamondbacksDBACKS.tvFubo, DirecTV StreamAtlanta BravesFanDuel Sorts Network SouthFubo, DirecTV StreamBaltimore OriolesMid-Atlantic Sports NetworkFubo, DirecTV StreamBoston Red SoxNew England Sports NetworkFubo, DirecTV Stream, NESN 360Chicago CubsMarquee Sports NetworkFubo, DirecTV StreamChicago White SoxNBC Sports ChicagoFubo, DirecTV StreamCincinnati RedsFanDuel Sports Network OhioFubo, DirecTV StreamCleveland GuardiansFanDuel Sports Network Great LakesFubo, DirecTV StreamColorado RockiesROCKIES.tvDirecTV StreamDetroit TigersFanDuel Sorts Network DetroitFubo, DirecTV Stream, FanDuel+Houston AstrosSpace City Home NetworkFubo, DirecTV StreamKansas City RoyalsFanDuel Sports Network Kansas CityFubo, DirecTV Stream, FanDuel+Los Angeles AngelsFanDuel Sports Network WestFubo, DirecTV StreamLos Angeles DodgersSportsNet Los AngelesDirecTV StreamMiami MarlinsFanDuel Sports Network FloridaFubo, DirecTV Stream, FanDuel+Milwaukee BrewersFanDuel Sports Network WisconsinFubo, DirecTV Stream, FanDuel+Minnesota TwinsFanDuel Sports Network NorthFubo, DirecTV StreamNew York MetsSportsNet New YorkFubo, DirecTV StreamNew York YankeesYES NetworkFubo, DirecTV StreamOakland AthleticsNBC Sports CaliforniaFubo, DirecTV StreamPhiladelphia PhilliesNBC Sports PhiladelphiaFuboPittsburgh PiratesSportsNet PittsburghFubo, DirecTV StreamSan Diego PadresPadres.TVFubo, DirecTV StreamSan Francisco GiantsNBC Sports Bay AreaFubo, DirecTV StreamSeattle MarinersROOT SportsFubo, DirecTV StreamSt Louis CardinalsFanDuel Sports Network MidwestFubo, DirecTV StreamTampa Bay RaysFanDuel Sports Network SunFubo, DirecTV Stream, FanDuel+Texas RangersFanDuel Sports Network SouthwestFubo, DirecTV StreamToronto Blue JaysSportnet (Canada)N/AWashington NationalsMid-Atlantic Sports NetworkFubo, DirecTV StreamChicago Cubs vs St. Louis Cardinals: Date and First-Pitch Time
The Chicago Cubs are set to host the St. Louis Cardinals to open the pivotal three-game series on September 26, 2025, at 2:20 pm ET/11:20 am PT at Wrigley Field in Chicago, Illinois.
DateSeptember 26, 2025First-Pitch Time2:20 pm ET/11:20 am PTVenueWrigley FieldLocationChicago, IllinoisStreaming the game with a VPN
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Chicago Cubs vs St. Louis Cardinals team newsChicago Cubs team news
Michael Busch has 31 home runs, a .255 batting average, and 84 RBIs.
Nico Hoerner has a .299 batting average, .348 on-base percentage, and .393 slugging percentage.
Seiya Suzuki has a batting average of .244 and has driven in 97 RBIs with 29 home runs.
Chicago Cubs injury reportPlayerPositionInjuryInjury StatusCade HortonSPBack injuryDay-to-DayMiguel AmayaCLeft ankle sprainOut, 10-Day ILSt. Louis Cardinals team news
Willson Contreras has scored 80 RBIs, 20 home runs, and a .257 batting average.
Alec Burleson has been hitting .293 with a slugging percentage of .464 and an on-base percentage of .345.
Kyle Leahy has a 4-2 record and a 3.18 ERA.
St. Louis Cardinals injury reportPlayerPositionInjuryInjury StatusWillson ContrerasINFRight shoulder strainOut, 10-Day ILMasyn WinnSSRight knee injuryOut, 10-Day ILChicago Cubs and St. Louis Cardinals projected starting pitchersDateChicago CubsSt. Louis CardinalsSeptember 26, 2025Colin ReaMiles MikolasSeptember 27, 2025Javier AssadMichael McGreevySeptember 28, 2025Jameson TaillonTBDChicago Cubs and St. Louis Cardinals head-to-head record
The outcomes of the last five meetings between the Chicago Cubs and the St. Louis Cardinals indicate a back-and-forth contest in which no side has a clear advantage. The Cubs demonstrated their capacity to score runs rapidly with two strong offensive performances, winning 9-1 on August 10, 2025, and 11-0 on July 7, 2025.
The Cardinals, on the other hand, responded with three convincing wins, including a close 3-2 triumph on August 11, a shutout 5-0 victory on August 9, and a thrilling 8-6 victory on July 5, demonstrating their ability to outslug and outpitch the Cubs.
This game might go any way because both teams have been able to trade momentum and produce convincing victories. The difference will probably come down to pitching consistency and whichever lineup settles into a groove first.
DateResultsAug 11, 2025Cardinals 3-2 CubsAug 10, 2025Cubs 9-1 CardinalsAug 09, 2025Cardinals 5-0 CubsJul 07, 2025Cubs 11-0 CardinalsJul 05, 2025Cardinals 8-6 CubsMore MLB news and coverage