The Washington Nationals (19-27) and Baltimore Orioles (15-28) play the second game of their 3-game series Saturday. First pitch from Oriole Park at Camden Yards is set for 4:05 p.m. ET (FS1). Let’s analyze BetMGM Sportsbook’s MLB odds around the Nationals vs. Orioles odds and make our expert MLB picks and predictions for the best bets.

Season series: Nationals lead 3-1

The Nationals secured a 4-3 win Friday night, thanks to home runs from 1B Nathaniel Lowe and DH James Wood, whose 12th of the season ranks among the top 10 in MLB. The game was decided in the ninth inning, as Washington scored the go-ahead run on a throwing error. The victory marked its second in the last 3 games.

OF Ramon Laureano went 4-for-4 with an RBI double, and 2B Jackson Holliday contributed a 3-for-5 performance with an RBI to help the Orioles. However, RP Felix Bautista took his first loss of the season, allowing the game-winning run in the ninth on his own throwing error. The loss extended Baltimore’s skid to 4 straight defeats.

Nationals at Orioles projected starters

RHP Jake Irvin vs. LHP Kyle Gibson

Irvin (2-1, 4.00 ERA) is making his tenth start. He has a 1.19 WHIP, 2.7 BB/9 and 5.7 K/9 in 54 innings.

Last start: No-decision, 6 IP, 3 ER, 7 H, 2 BB, 1 K in 4-3 road setback at Atlanta Braves Monday2025 road stats: 2-1, 3.91 ERA (25 1/3 IP, 11 ER), 21 H, 6 BB, 18 K in 4 startsCareer vs. Orioles: 1 road start (Aug. 13, 2024), win, 6 IP, 2 ER, 7 H, 1 BB, 3 K in 9-3 victory

Gibson (0-2, 13.11 ERA) is making his fourth start. He has a 1.19 WHIP, 2.7 BB/9 and 5.7 K/9 in 54 innings.

Last start: Loss, 4 IP, 5 ER, 7 H, 3 BB, 4 K in 5-2 road defeat at Los Angeles Angels May 102025 home stats: 0-1, 14.09 ERA (7 2/3 IP, 12 ER), 7 H, 3 BB, 5 K in 2 startsLast start vs. Nationals: Loss, 5 IP, 2 ER, 6 H, 3 BB, 0 K in 14-3 road defeat July 27, 2024Career vs. Nationals: 2-4, 7.11 ERA (31 1/3 IP, 25 ER), 1.73 WHIP, 7.2 K/9 in 6 starts

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Nationals at Orioles odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:25 a.m. ET.

Moneyline (ML): Nationals +135 (bet $100 to win $135) | Orioles -160 (bet $160 to win $100)Run line (RL)/Against the spread (ATS): Nationals +1.5 (-155) | Orioles -1.5 (+125)Over/Under (O/U): 10 (O: -110 | U: -110)Nationals at Orioles picks and predictionsPrediction

Nationals 4, Orioles 2

BET NATIONALS (+135).

I’m going with the Nationals to keep up their recent success against Baltimore, having won 4 of their last 6 matchups and outscoring the Orioles 26-15 during that stretch. While Irvin isn’t flashy, he’s capable of getting the job done. Gibson, however, has been a major issue for Baltimore, struggling in all 3 of his starts this season. He hasn’t made it past the fifth inning in any outing and has allowed 7 home runs in just 11 2/3 innings.

Baltimore has also struggled at home, with a disappointing 8-13 record at Camden Yards. Its offense is underperforming, hitting just .240 as a team, and C Adley Rutschman, expected to be a key part of the lineup, is batting only .200 at home and .214 overall.

Meanwhile, the Nationals have the young stud Wood, who’s batting .273 with 27 RBIs, providing much-needed production from the heart of the order.

With these factors, I’m taking the plus odds on Washington to win outright as the road underdog Saturday afternoon.

PASS.

Stay away from the run line. I’d only be interested in getting the Nationals, but not at these odds.

BET UNDER 10 (-110).

I’m all in on the Under for this matchup, and the trends strongly support that bet. The Under has hit in 8 straight meetings. Additionally, it’s 6-3-1 in the Nationals’ last 10 games and 6-4 in the Orioles’ last 10. Washington lacks offensive firepower outside of Wood, scoring over 5 runs just once in its last 10 games. The Orioles haven’t been much better, scoring more than 5 runs just twice in their last 10. Given these factors, the Under is the smart play.

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