The San Francisco 49ers (5-3) visit the New York Giants (2-6) at MetLife Stadium in East Rutherford for a Week 9 showdown, and USA TODAY’s panel of NFL experts have locked in their picks and predictions for the action. Here’s everything you need to know before kickoff on Sunday, November 2, including live updated odds and injury report news.

NameWeek 82025 SeasonJon Hoefling4-962-56-3Tyler Dragon10-362-56-3Blake SchusterN/A55-50-3Richard Morin8-525-12-1Lorenzo Reyes7-657-61-3Chris Bumbaca5-854-64-3Jordan Mendoza7-646-43-2Giants vs. 49ers live odds, moneyline, over/under

Opening Lines

Spread: San Francisco 49ers (-3.5)Moneyline: San Francisco 49ers (-185), New York Giants (+160)Over/Under: 44.5

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Jon Hoefling: San Francisco 49ers (-2.5)

An embarrassing loss against Houston should propel this 49ers team to a win over New York. Furthermore, the loss of Cam Skattebo could be much more harmful than we think. It’s easy to forget just how bad Tyrone Tracy Jr. and Devin Singletary have been this year.

Jordan Mendoza: San Francisco 49ers (-2.5)

The loss of Cam Skattebo really hurts New York, and the offense will get an angry 49ers team coming off a disappointing performance against Houston. San Francisco is too physical.

Tyler Dragon: San Francisco 49ers (-2.5)

The 49ers and Giants are both dealing with injuries to key players. San Francisco still has Christian McCaffrey, George Kittle and Trent Williams. That’s the difference.

Christopher Bumbaca: San Francisco 49ers (-2.5)

No Cam Skattebo, no Malik Nabers. Jaxson Dart is the guy but there’s just too many holes for him to cover for the Giants to … Cover.

Lorenzo Reyes: San Francisco 49ers (-2.5)

That was an uncharacteristic loss for the Niners, and the Giants will be reeling with key season-ending injuries on offense now to Cam Skattebo, in addition to the Malik Nabers one from several weeks ago. I think this is solid value here.

Blake Schuster: San Francisco 49ers (-2.5)

Two extremely beat up teams. The difference is this San Francisco core was born with the injury bug, molded by it.

Giants vs. 49ers updated injury reportNFL Week 9 picks, predictions odds

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