The San Francisco 49ers (5-3) will meet the New York Giants (2-6) on Sunday, November 2, 2025 at MetLife Stadium. The line forecasts a close game, with the 49ers favored by 2.5 points. The over/under is 48.5 in the contest.
In their most recent game, the 49ers lost versus the Houston Texans, 26-15.
The Niners’ Mac Jones went 19-for-32 for 193 yards against the Texans, with two TDs and one INT.
Facing the Philadelphia Eagles in their last contest, the Giants lost 38-20.
49ers vs Giants betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 8:47 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread favorite: San Francisco (-2.5)Moneyline: San Francisco (-145), New York (+122)Total: 48.5 points49ers betting insightsThis season on the road, San Francisco is 3-2 against the spread and 3-2 overall.The 49ers are 4-4-0 against the spread this season.San Francisco is unbeaten ATS (1-0) as 2.5-point favorites or more on the road.The 49ers have an ATS record of 1-1 when playing as at least 2.5-point favorites.This season, in five road games, San Francisco has hit the over three times.This season, four 49ers games have gone over the point total.49ers leadersJones: 1,597 PASS YDS / 266.2 YPG / 65.9% / 8 TD / 5 INTChristian McCaffrey: 140 CAR / 490 YDS / 61.3 YPG / 3 TD / 56 REC / 559 YDS / 69.9 YPG / 3 TDBrian Robinson Jr.: 36 CAR / 144 YDS / 18 YPG / 0 TD / 5 REC / 11 YDS / 1.4 YPG / 0 TDKendrick Bourne: 28 REC / 429 YDS / 61.3 YPG / 0 TDRicky Pearsall: 20 REC / 327 YDS / 81.8 YPG / 0 TD49ers vs Giants game infoDate: Sunday, November 2, 2025Time: 1 p.m. ETCity: East Rutherford, New JerseyVenue: MetLife StadiumTV channel: CBSLive stream: Watch on Fubo (Regional restrictions may apply)Live stream: Watch on Paramount+ (Regional restrictions may apply)
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