Harrison Bader and the Minnesota Twins will square off against Jose Ramirez and the Cleveland Guardians at Target Field in the first of a two-game series, Wednesday at 3:40 p.m. ET.
The Twins are 16th in the majors with a .243 batting average. The Guardians rank 23rd in MLB with a .233 team batting average.
Ahead of the Twins vs. Guardians matchup, here is everything you need to prepare for Wednesday’s baseball action, including viewing options.
Twins vs. Guardians: live stream info, TV channel & game timeGame day: Wednesday, May 21, 2025Game time: 3:40 p.m. ETLocation: Minneapolis, MinnesotaStadium: Target FieldTV channel: MLB.TV – Cleveland GuardiansLive stream: Watch LIVE with Fubo! (Regional restrictions may apply)
Twins vs. Guardians odds & betting linesFavorite: Twins (-121, bet $121 to win $100)Underdog: Guardians (+101, bet $100 to win $101)Over/under: 7.5
MLB odds courtesy of BetMGM Sportsbook. Odds updated Wednesday at 3:09 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.