A series opener between the Pittsburgh Pirates (21-36) and San Diego Padres (31-23) is on deck Friday at 9:40 p.m. ET, at PETCO Park.

The Padres are the home favorite (-200) against the Pirates (+167). The matchup on the mound for this contest is set with the San Diego Padres looking to Nick Pivetta (5-2), and Mitch Keller (1-6) getting the nod for the Pittsburgh Pirates.

The Padres’ matchup Wednesday versus the Marlins ended in a 10-8 loss. Gavin Sheets went 2 for 3 with a home run and three RBIs in the defeat, while Jason Adam threw 2/3 of an inning without giving up an earned run on three hits en route to taking the loss.

The Pirates beat the Diamondbacks 10-1 Wednesday. Isiah Kiner-Falefa led the way offensively after going 3 for 4 with two doubles and two RBIs, and Paul Skenes got the win, pitching 6 2/3 innings without giving up an earned run on four hits, while striking out seven.

Before watching this Padres vs. Pirates matchup, here is everything you need to know about Friday’s action on the diamond, including viewing options.

San Diego Padres vs. Pittsburgh Pirates odds, line and spread

MLB odds courtesy of BetMGM Sportsbook. Odds updated Thursday at 6:17 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

Favorite: Padres (-200, bet $200 to win $100)Underdog: Pirates (+167, bet $100 to win $167)Over/under: 7.5Padres vs. Pirates: Game time and live stream infoGame day: Friday, May 30, 2025Game time: 9:40 p.m. ETLocation: San Diego, CaliforniaStadium: PETCO ParkTV channel: MLB Network, SDPA, and SportsNet PTLive stream: Watch LIVE with Fubo! (Regional restrictions may apply)

Watch Padres vs. Pirates on Fubo!

Padres stats and trendsPadres betting recordsThe Padres have won 19, or 61.3%, of the 31 games they’ve played as favorites this season.San Diego has a record of 4-2 in games when sportsbooks favor them by at least -200 on the moneyline.The moneyline for this contest implies a 66.7% chance of a victory for the Padres.So far this season, San Diego and its opponents have hit the over in 23 of 54 games with a total.The Padres are 29-25-0 against the spread in their 54 chances this season.Nick Pivetta (Padres probable starter)Pivetta (5-2) takes the mound for the Padres in his 11th start of the season. He’s put together a 2.72 ERA in 56 1/3 innings pitched, with 63 strikeouts.In his most recent outing on Friday against the Atlanta Braves, the right-hander went six innings, allowing one earned run while surrendering four hits.In 10 games this season, the 32-year-old has a 2.72 ERA and 10.1 strikeouts per nine innings, while allowing a batting average of .192 to opposing batters.Pivetta is trying to register his third straight quality start in this matchup.Pivetta will look to pitch five or more innings for his third straight appearance. He’s averaging 5.6 innings per outing.He has had three appearances this season in which he did not allow an earned run.The opposing Pirates offense has the worst slugging percentage (.337) and ranks 29th in MLB play with 40 home runs. It has a collective .226 batting average, and is 24th in MLB with 428 total hits and 29th in MLB play scoring 183 runs.Among qualifying pitchers in MLB play this season, the 32-year-old’s 2.72 ERA ranks 20th, 1.012 WHIP ranks 16th, and 10.1 K/9 ranks 16th.Padres batting statsThe Padres’ 52 home runs rank 21st in Major League Baseball.Fueled by 138 extra-base hits, San Diego ranks 16th in MLB with a .391 slugging percentage this season.The Padres rank ninth in MLB with a .253 team batting average.San Diego has scored the 16th-most runs in the majors this season with 233 (4.3 per game).The Padres have an OBP of .319 this season, which ranks 14th in MLB.San Diego has the fewest strikeouts in MLB, whiffing only 7.0 times per game on average.Pirates stats and trendsPirates betting recordsThe Pirates have come away with 15 wins in the 40 contests they have been listed as the underdogs in this season.This season, Pittsburgh has been victorious four times in nine chances when named as an underdog of at least +167 or longer on the moneyline.The Pirates have an implied victory probability of 37.5% according to the moneyline set by oddsmakers for this matchup.Pittsburgh and its opponents have gone over the total this season in 23 of its 57 opportunities.In 57 games with a line this season, the Pirates have a mark of 24-33-0 against the spread.Mitch Keller (Pirates probable starter)Keller (1-6 with a 3.66 ERA and 55 strikeouts in 64 2/3 innings pitched) gets the start for the Pirates, his 12th of the season.In his most recent appearance on Saturday, the righty threw six innings against the Milwaukee Brewers, allowing one earned run while surrendering seven hits.The 29-year-old has put up an ERA of 3.66, with 7.7 strikeouts per nine innings in 11 games this season. Opponents are batting .262 against him.Keller is trying to build upon a fourth-game quality start streak in this outing.Keller will try to go five or more innings for his 10th straight appearance. He’s averaging 5.8 innings per outing.He has held his opponents without an earned run in one of his 11 appearances this season.He will take the hill against a Padres offense that ranks 14th in the league with 457 total hits (on a .253 batting average). The team also slugs a collective .391 (16th in the league) with 52 total home runs (21st in MLB action).Keller has a 7.20 ERA and a 1.8 WHIP against the Padres this season in five innings pitched, allowing a .364 batting average over one appearance.The 29-year-old’s 3.66 ERA ranks 51st, 1.297 WHIP ranks 60th, and 7.7 K/9 ranks 45th among qualifying pitchers this season.Pirates batting statsThe Pirates are second-worst in MLB play with 40 home runs.This season, Pittsburgh’s .337 slugging percentage is the lowest percentage in baseball.The Pirates are 26th in the majors with a .226 batting average.The offense for Pittsburgh is No. 29 in MLB play scoring 3.2 runs per game (183 total runs).The Pirates’ .306 on-base percentage ranks 22nd in MLB.

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