The Chicago Cubs will square off with the Los Angeles Angels in MLB action at Wrigley Field on Wednesday, beginning at 2:20 PM ET.

Matthew Boyd (0-1, 14.73 ERA) will be the starting pitcher for the Cubs, while the Angels will counter with Yusei Kikuchi (0-0, 4.15 ERA).

Based on the latest simulation results, Dimers’ proven MLB model projects the Cubs as the most likely winner of the Angels vs. Cubs game.

This article offers further insights into Wednesday’s matchup, including best bets and picks.

Angels vs. Cubs prediction: Who will win and cover?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Wednesday’s MLB matchup between the Angels and Cubs, forming part of our MLB predictions coverage.

Our leading predictive model currently gives the Cubs a 61% chance of beating the Angels.

According to our model, the Angels (+1.5) have a 59% chance of covering the run line, while the 6-run over/under has a 57% chance of going over.

 

Angels vs. Cubs odds [4/1/2026]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type
Angels
Cubs

Run Line
+1.5 (-170)
-1.5 (+149)

Moneyline
+145
-160

Total
o6 (-104)
u6 (-110)

All odds are correct at the time of publication and are subject to change.

Angels vs. Cubs picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: