SAN DIEGO — The Giants couldn’t finish off the first sweep of the Tony Vitello era, falling 7-1 to the San Diego Padres on Wednesday afternoon at Petco Park.

San Francisco’s (2-4) first road trip of the season ended on a dour note between José Buttó’s elbow/forearm injury and a heated moment between Matt Chapman and Casey Schmitt. Still, between Tony Vitello’s first career managerial win on Monday and Logan Webb’s gutsy outing on Tuesday, the Giants’ time in San Diego was a net positive.

“I think the guys found themselves a little bit getting away from home and spending our true first road trip,” Vitello said. “We get a series win today.”

Right-hander Adrian Houser took the loss as he allowed three runs (one earned) over 5 1/3 innings with four strikeouts to one walk in his Giants debut. Both of Houser’s unearned runs were directly the product of first baseman Schmitt failing to haul in a pair of throws from third baseman Chapman in the first and fifth innings.

Schmitt was charged with an error in the first, while Chapman was dinged with an error in the fifth despite delivering a throw that was catchable but slightly high. Cameras caught Chapman appearing to tell Schmitt to “catch the (expletive) ball” during a mound visit after the play in the fifth inning. Following the game, both infielders said they talked things over and that there’s no problem.

“We’re brothers here,” Chapman said. “Heat of the moment. I’ve already talked to Casey. It’s all good.”

Said Schmitt: “We’re trying to win games. I’m not mad about it or anything like that.”

Following Tuesday night’s nine-run, 16-hit offensive outburst, San Francisco’s offense had just four hits and struck out 14 times. Former Padre Luis Arraez, who received a tribute video on Monday, was one of the Giants’ lone bright spots, recording his first three-hit game as a Giant.

Opposite Houser, Nick Pivetta turned in another excellent start against the Giants, pitching five scoreless innings with eight strikeouts and allowing just one hit. At one point, Pivetta struck out five straight batters (all swinging). Over his last three starts against San Francisco, Pivetta has allowed just two runs over 17 2/3 innings (1.02 ERA) with 23 strikeouts.

Rookie catcher Daniel Susac, the younger brother of former Giant Andrew Susac, made his major league debut in the bottom of the seventh inning, entering the game after Jerar Encarnacion pinch-hit for Patrick Bailey in the top of the inning. Susac recorded a 2-1 double play in the bottom of the eighth, fielding a ball right in front of home, stepping on the plate, then firing to first.

Buttó exited the ballgame with a trainer in the eighth inning after allowing four runs, issuing four walks and recording just one out.  Along with erratic command, Buttó’s fastball barely touched 90 mph by the end of his outing. Vitello said postgame that Buttó was dealing with elbow/forearm tightness.

“All I know is there was clearly tightness,” Vitello said. “He wasn’t throwing the ball as well as possible the whole time. And Chappy, again, same thing leadership-wise, went out there to visit with him. He didn’t speak of any discomfort then, but he did when we visited, and it was probably time for him to come out anyway, pitch count-wise at that point.”

The Padres took a 1-0 lead in the bottom of the first when Jackson Merrill scored on Manny Machado’s infield single. Chapman delivered an accurate throw, but Schmitt couldn’t catch it clean and was charged with an error.

In the bottom of the fifth, the Giants’ second error of the game resulted in the Padres’ second run of the game. With two outs and runners on first and third, Chapman fielded Xander Bogaerts’ slow chopper and fired a throw on the run that was a little too high, deflecting off Schmitt’s glove and allowing Gavin Sheets to score. Chapman was charged with the throwing error, but the throw was definitely catchable for Schmitt.

Houser surrendered his first earned run of the season in the bottom of the sixth when Sheets drove in Ramón Laureano on a double, prompting Vitello to go to his bullpen with the Giants trailing 3-0.

The Giants scored their first run of the afternoon in the seventh when Harrison Bader singled home Arraez, who had doubled, cutting the Padres’ lead to 3-1. With the left-hander Adrian Morejon on the mound, Vitello used a pinch-hitter for the first time all season by having Encarnacion bat for the switch-hitting Bailey.

While Vitello got an advantageous matchup, Encarnacion softly grounded out in his first at-bat of the season.