April 4, 2026, 4:37 p.m. ET

The Philadelphia Phillies (4-3) and Colorado Rockies (2-5) play Saturday in the second game of a 3-game series at Coors Field in Denver, Colorado. First pitch is slated for 8:10 p.m. ET. Let’s analyze MLB odds around the Phillies vs. Rockies odds and make our expert MLB picks and predictions for the best bets.

Season series: Phillies lead 1-0

Philadelphia jumped on Colorado SP Michael Lorenzen (3 IP, 9 ER, 12 H, 2 BB, 2 K) from the get-go, scoring 7 runs in the top of the first inning en route to a 10-1 rout Friday, spoiling the Rockies’ home opener. The Phillies were -190 favorites as the Over (10) cashed.

Philly’s first 5 batters reached — SS Trea Turner double, DH Kyle Schwarber walk, 1B Bryce Harper walk, 3B Alec Bohm RBI single, 2B Bryson Stott 2-run double — before LF-RF Brandon Marsh smacked a 1-out, 3-run homer for a 6-0 lead. The Phillies batted around, making it 7-0 on a Turner, 2-out single.

That’s was more than enough cushion for SP Aaron Nola (1-0), who allowed 1 run on 5 hits and a walk over 6 1/3 innings, while striking out 9. Three Philly relievers completed the job with 2 2/3 innings of hitless, scoreless ball.

Turner finished 3 for 4 with 2 runs and an RBI, while Harper (solo HR in second), Bohm and Stott recorded 2 hits apiece. Schwarber (1 for 3, 2 R, 1 RBI) also went yard as the Phillies won a third consecutive game and their first road game of the season.

The Rockies couldn’t follow up their exciting 2-1, 10-inning win at the Toronto Blue Jays Wednesday, but they did take 2 of 3 from the AL champions. They roughed up the Jays 14-5 in Monday’s opener after dropping their first 3 games in Miami.

Watch MLB on Fubo!Phillies at Rockies projected starters

LHP Jesus Luzardo vs. LHP Brennan Bernardino

Luzardo (0-1, 9.00 ERA) makes his second start of the short season. He was 15-7 with a 3.92 ERA, 1.22 WHIP, 2.8 BB/9 and 10.6 K/9 through 183 2/3 innings across 32 starts last season.

Last start: Loss, 6 IP, 6 ER, 6 H, 1 BB, 7 K in a 8-3 setback at home vs. Texas Rangers on Sunday2025 on the road: 7-5, 3.67 ERA (90 2/3 IP, 37 ER), 1.32 WHIP, 9.9 K/9 in 16 startsCareer vs. Rockies: 1-1, 5.40 ERA (23 1/3 IP, 14 ER), 1.41 WHIP, 12.3 K/9 in 5 games (3 starts)2025 vs. Rockies: 1 start, win, 6 IP, 1 ER, 2 H 3 BB, 10 K in 7-4 victory at Coors FieldCareer at Coors: 1-1, 7.11 ERA (12 2/3 IP, 10 ER), 13 H, 7 BB, 14 K in 3 games (2 starts)

Bernardino (1-0, 0.00 ERA) makes his first start, slated as an “opener” after 4 relief appearances to start the season. He was 4-3 with a 3.14 ERA, 1.26 WHIP, 4.5 BB/9 and 7.5 K/9 in 51 2/3 innings across 55 games (3 starts) for the Boston Red Sox in 2025.

Last outing: Win, 1 IP in relief, 0 ER, 0 H, 0 BB, 0 K in the 2-1 victory at Blue Jays on WednesdayCareer vs. Phillies: 0-0, 2.08 ERA (4 1/3 IP, 1 ER), 1.15 WHIP, 3 H, 2 BB, 4 K in 4 relief appearancesCareer at Coors: 0-0, 4.50 ERA (2 IP, 1 ER), 2.00 WHIP, 4 H, 0 BB, 4 K in 2 relief outingsPhillies at Rockies odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 4:30 p.m. ET.

Moneyline (ML): Phillies -230 (bet $230 to win $100) | Rockies +190 (bet $100 to win $190)Run line (RL)/Against the spread (ATS): Phillies -1.5 (-152) | Rockies +1.5 (+126)Over/Under (O/U): 10.5 (O: -105 | U: -115)

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Phillies at Rockies picks and predictionsPrediction

Rockies 8, Phillies 7

It’s no secret that Philadelphia (-230) is the better club, but baseball teams don’t win every game and go 162-0. There’s value in the COLORADO (+190) price, which is what we should be looking to take advantage of.

Don’t bet anything crazy, but there’s value in wagering a little pizza money on this one. The Rockies did just take 2 of 3 in Toronto, cashing as +235 and +225 underdogs. Plus, the home crowd should be into as it’s the first Saturday night home game of the season.

BetMGM Sportsbook is offering a better line at ROCKIES (+200).

PASS since we’re on the Colorado ML.

Most books are offering the Phillies at -1.5 with juice of -150 or more. There’s really no value there.

If you strongly believe the Phillies are going to roll again, BetMGM has a line of Philly -2.5 (+100) at even-money.

BET OVER 10.5 (-105).

Luzardo struggled in his opener, giving up 6 runs in 6 innings to the Rangers. Look for the 8-year veteran southpaw to struggle again.

Plus, with the Rockies starting an opener, who knows what is coming out of their bullpen. However, they were in “save-mode” Friday, only using 1 reliever in the blowout loss — RHP Valente Bellozo pitched the final 6 innings (1 ER, 1 H, 1 BB, 7K) after Lorenzen was removed.

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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