The Orioles are -145 favorites vs the White Sox

Orioles vs White Sox Over / Under today: 8.5 Runs

Orioles / White Sox TV Channel: MASN | CHSN

The Baltimore Orioles (-145) visit Rate Field to take on the Chicago White Sox (+120) on April 6, 2026. First pitch is scheduled for 7:40 pm in Chicago, IL.

This season, the Orioles are 3-6 against the spread (ATS), while the White Sox are 4-5 ATS.

Orioles vs White Sox Starting Pitchers Today:

Orioles starting pitcher: Zach Eflin 0-0, 2.46 ERA

White Sox starting pitcher: Grant Taylor 0-0, 2.25 ERA

Orioles vs. White Sox Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneylineOrioles-1.5 +110O 8.5 +105-145White Sox +1.5 -130U 8.5 -125+120

Based on recent trends the model predicts the Orioles will win Monday‘s MLB game with 58.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Orioles players for Monday‘s game, looking at profitable historical betting trends:

Best Orioles Player Prop Bets Today:

Coby Mayo has hit the Home Runs Over in 4 of his last 10 away games (+20.60 Units / 206% ROI)

Pete Alonso has hit the Runs Under in 16 of his last 20 away games (+10.20 Units / 36% ROI)

Colton Cowser has hit the Singles Under in his last 10 away games (+10.00 Units / 46% ROI)

Pete Alonso has hit the Hits Over in 16 of his last 20 games (+8.00 Units / 18% ROI)

Taylor Ward has hit the Walks Under in 12 of his last 15 away games (+7.85 Units / 28% ROI)

And here are some favorite MLB player prop bets for White Sox players for Monday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Best Bets Today:

Munetaka Murakami has hit the Home Runs Over in 4 of his last 9 games (+15.20 Units / 169% ROI)

Miguel Vargas has hit the Runs Over in 16 of his last 25 games at home (+13.40 Units / 54% ROI)

Colson Montgomery has hit the Singles Over in 13 of his last 20 games (+11.85 Units / 59% ROI)

Miguel Vargas has hit the Hits Runs and RBIs Over in 14 of his last 20 games (+9.45 Units / 43% ROI)

Chase Meidroth has hit the Hits Under in 10 of his last 15 games (+9.30 Units / 48% ROI)

Orioles Best Bets Today:

The Baltimore Orioles have hit the Game Total Under in 87 of their last 141 games (+30.03 Units / 19% ROI)

The Baltimore Orioles have hit the Team Total Under in 84 of their last 142 games (+17.65 Units / 10% ROI)

The Baltimore Orioles have hit the 1st Five Innings (F5) Team Total Over in 25 of their last 39 away games (+10.75 Units / 23% ROI)

The Baltimore Orioles have hit the Moneyline in 59 of their last 113 games (+9.85 Units / 8% ROI)

The Baltimore Orioles have covered the Run Line in 45 of their last 76 games (+8.05 Units / 8% ROI)

White Sox Best Bets Today:

The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in 45 of their last 69 games at home (+16.45 Units / 19% ROI)

The Chicago White Sox have covered the Run Line in 82 of their last 138 games (+15.05 Units / 8% ROI)

The Chicago White Sox have hit the Team Total Over in 41 of their last 66 games (+13.60 Units / 18% ROI)

The Chicago White Sox have hit the 1st Five Innings (F5) Moneyline in 29 of their last 71 games at home (+9.95 Units / 14% ROI)

The Chicago White Sox have hit the Game Total Under in 11 of their last 16 games (+5.60 Units / 32% ROI)

Orioles Against the Spread (ATS) Record

Against the spread this season, the Orioles are 2-7 against the Run Line (-6.25 Units / -56.31% ROI).

3-6 when betting on the Moneyline for -4.25 Units / -37.61% ROI

5-4 when betting on the total runs Over for +0.55 Units / 5.58% ROI

4-5 when betting on the total runs Under for -1.6 Units / -16.08% ROI

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 4-5 against the Run Line (-3.7 Units / -28.35% ROI).

4-5 when betting on the Moneyline for +0.55 Units / 6.11% ROI

7-2 when betting on the total runs Over for +4.8 Units / 48.98% ROI

2-7 when betting on the total runs Under for -5.8 Units / -58% ROI

Orioles Keys to the Game vs. the White Sox

The Orioles were just 1-77 (.013) when trailing entering the 9th inning in the 2025 season — 3rd lowest in MLB; League Avg: .043.

The Orioles were just 12-51 (.190) when allowing 10 or more hits in the 2025 season — 5th lowest in MLB; League Avg: .256.

The Orioles were just 63-10 (.863) when leading entering the 8th inning in the 2025 season — 5th lowest in MLB; League Avg: .909.

The Orioles were 65-20 (.765) when they allowed 4 or fewer runs in the 2025 season — 5th best in MLB; League Avg: .714.

White Sox Keys to the Game vs. the Orioles

The White Sox are just 84-38 (.689) when leading entering the 7th inning since the 2024 season — lowest in MLB; League Avg: .867.

The White Sox are just 89-23 (.795) when leading entering the 8th inning since the 2024 season — lowest in MLB; League Avg: .904.

The White Sox are just 35-198 (.150) when scoring 4 or fewer runs since the 2024 season — lowest in MLB; League Avg: .281.

The White Sox were just 55-6 (.902) when leading entering the 9th inning in the 2025 season — lowest in MLB; League Avg: .956.

Orioles Hitting Stats & Trends

The Orioles batted just .229 on the road in the 2025 season — tied for 5th lowest in MLB.

Orioles hitters are slugging just .353 on the first pitch of at-bats this season — 3rd lowest in MLB.

Orioles hitters had 99 extra-base hits out of 225 total hits (44%) on the first pitch of at-bats in the 2025 season — best in MLB.

Orioles hitters had an OPS of just .671 (3,064 PA’s) on the road in the 2025 season — 4th lowest in MLB.

White Sox Hitting Stats & Trends

The White Sox won only 33% of their road games in the 2025 season — tied for 2nd lowest in MLB.

The White Sox have a winning percentage of just 27% on the road since the 2024 season — 2nd lowest in MLB.

The White Sox have a winning percentage of just 32% since the 2024 season — lowest in MLB.

White Sox hitters have struck out in 47% of their PA’s in lefty-lefty matchups this season — highest in MLB.

Orioles Pitching Stats & Trends

Orioles pitchers walked 10% of batters when facing the leadoff batter in the inning in the 2025 season — 2nd highest in MLB.

Orioles pitchers have walked 10% of batters when facing the leadoff batter in the inning since the 2025 season — 2nd highest in MLB.

Orioles pitchers won only 16% of games in which they allowed their opponent to score in three different innings in the 2025 season — 3rd lowest in MLB.

In games when their opponents scored three or more runs in an inning, the Orioles won just 11% of the time in the 2025 season — lowest in MLB.

White Sox Pitching Stats & Trends

Opponents have a miss rate of just 20% against White Sox pitchers this season — 2nd lowest in MLB.

The White Sox have won just 9% of road games in which their opponents scored first since the 2024 season — lowest in MLB.

White Sox pitchers walked 10% of batters in the 2025 season — 2nd highest in MLB.

The White Sox have won just 15% of games in which their opponents scored first since the 2024 season — lowest in MLB.

More MLB Reading:

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