April 11, 2026, 11:17 a.m. ET
The Boston Red Sox (4-9) and St. Louis Cardinals (8-5) face off in the second game of their 3-game series Saturday. First pitch from Busch Stadium in St. Louis, Missouri, is scheduled for 7:15 p.m. ET (FOX). Let’s analyze MLB odds around the Red Sox vs. Cardinals odds and make our expert MLB picks and predictions for the best bets.
Season series: Cardinals lead 1-0.
The Red Sox lost the opener Friday 3-2, snapping a small 2-game winning streak. Reliever Zack Kelly came in during the fifth inning and allowed 2 runs in 2/3 of an inning. OF Wilyer Abreu had 2 of the Red Sox’s 5 hits for the game.
The Cardinals have won 3 games in a row. Starter Dustin May pitched 6 strong innings, allowing 2 runs (1 earned), on 4 hits and no walks, striking out 4, picking up his first win of the season. The bullpen pitched 3 scoreless innings of relief, with Riley O’Brien picking up his fourth save of the year.
Watch MLB on Fubo!Red Sox at Cardinals projected starters
LHP Ranger Suarez vs. RHP Kyle Leahy
Suarez (0-1, 8.64 ERA) makes his third start. He has a 1.92 WHIP, 3 BB and 5 K through 8 1/3 innings.
Last start: No-decision, 4 IP, 4 ER, 6 H, 2 BB, 2 K in an 8-6 home loss to the San Diego Padres SundayCareer vs. Cardinals: 1-0, 1.13 ERA (8 IP, 1 ER), 1.00 WHIP, 7.9 K/9 in 2 starts2025 road splits: 6-5, 2.84 ERA (76 IP, 24 ER), 1.21 WHIP, 7.8 K/9 in 12 starts
Leahy (1-1, 5.40 ERA) makes his third start. He has a 1.80 WHIP, 5 BB and 5 K through 10 innings.
Last start: Win, 5 IP, 2 ER, 5 H, 3 BB, 4 K in a 5-3 road victory over the Detroit Tigers SundayCareer vs. Red Sox: 0-0, 0.00 ERA (3 IP, 0 ER), 0.38 WHIP, 13.5 K/9 in 2 relief appearances2025 home splits: 2-1, 4.06 ERA (43 2/3 IP, 10 ER), 1.10 WHIP, 9.5 K/9 in 7 relief appearancesRed Sox at Cardinals odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:08 a.m. ET.
Moneyline (ML): Red Sox -135 (bet $135 to win $100) | Cardinals +110 (bet $100 to win $110)Run line (RL)/Against the spread (ATS): Red Sox -1.5 (+125) | Cardinals +1.5 (-155)Over/Under (O/U): 8 (O: -105 | U: -115)
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Red Sox at Cardinals picks and predictionsPrediction
Cardinals 4, Red Sox 3
The Red Sox have struggled on the road so far this season. They are 1-6 in away games and have lost 6 in a row. They have scored 3 or fewer runs in 5 of those 7 road games.
The Cardinals are 5-2 at home and have held opponents to 2 or fewer runs in 3 straight games at Busch Stadium. Suarez has not been good yet this season, allowing 4 runs in each start, failing to get out of the fifth inning each time. Boston is 0-2 in his outings.
BET CARDINALS (+110).
Boston is 2-8 ATS as favorites per TeamRankings.com, but only 1 of those ATS losses was an outright win.
The Cardinals are 6-4 ATS as underdogs, but all 6 covers have been outright wins, so if you like them to cover, bet them to win on the ML where you get plus odds.
PASS.
The series opener had a total of 5 runs. Five of the Cardinals’ last 6 wins have had totals under 8 runs.
Five of Boston’s last 7 games have not reached 8 total runs, scoring 3 or fewer runs in 5 of 7 road games.
BET UNDER 8 (-115).
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