The Astros are -145 favorites vs the Cardinals
Cardinals vs Astros Over / Under today: 8.5 Runs
Cardinals / Astros TV Channel: CATV | SCHN | ESUN
The St. Louis Cardinals (+118) visit Daikin Park to take on the Houston Astros (-145) on April 17, 2026. First pitch is scheduled for 8:10 pm in Houston, TX.
This season, the Cardinals are 10-8 against the spread (ATS), while the Astros are 8-12 ATS.
Cardinals vs Astros Starting Pitchers Today:
Cardinals starting pitcher: Kyle Leahy 1-2, 5.15 ERA
Astros starting pitcher: Peter Lambert 0-0, 0.00 ERA
Cardinals vs. Astros Odds, Run Line, Over/Under & Moneyline
SpreadOver / UnderMoneylineCardinals+1.5 -190O 8.5 -110+118Astros -1.5 +155U 8.5 -110-145
Based on recent trends the model predicts the Astros will win Friday‘s MLB game with 59.9% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.
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We’ve highlighted some favorite MLB player prop bets for Cardinals players for Friday‘s game, looking at profitable historical betting trends:
Best Cardinals Player Prop Bets Today:
Jordan Walker has hit the Home Runs Over in 6 of his last 9 games (+29.50 Units / 328% ROI)
Ivan Herrera has hit the Walks Over in 12 of his last 15 games (+14.85 Units / 99% ROI)
Jordan Walker has hit the Runs Over in 15 of his last 25 games (+12.65 Units / 50% ROI)
Jordan Walker has hit the Total Bases Over in 8 of his last 9 games (+9.20 Units / 94% ROI)
Jordan Walker has hit the Hits Over in 9 of his last 10 games (+8.00 Units / 41% ROI)
And here are some favorite MLB player prop bets for Astros players for Friday‘s game, looking at profitable historical betting trends:
Best Astros Player Prop Best Bets Today:
Christian Walker has hit the Total Bases Over in 18 of his last 25 games (+11.45 Units / 38% ROI)
Yordan Alvarez has hit the Runs Over in 13 of his last 15 games at home (+11.25 Units / 62% ROI)
Yordan Alvarez has hit the Hits Runs and RBIs Over in his last 9 games at home (+9.40 Units / 87% ROI)
Yordan Alvarez has hit the Home Runs Over in 4 of his last 9 games at home (+8.75 Units / 97% ROI)
Carlos Correa has hit the Hits Over in 16 of his last 20 games at home (+8.50 Units / 20% ROI)
Cardinals Best Bets Today:
The St. Louis Cardinals have hit the Game Total Over in 22 of their last 40 away games (+5.45 Units / 12% ROI)
The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Over in 14 of their last 21 away games (+5.25 Units / 20% ROI)
The St. Louis Cardinals have hit the Team Total Over in their last 5 away games (+5.10 Units / 86% ROI)
The St. Louis Cardinals have hit the Moneyline in 10 of their last 18 games (+3.15 Units / 17% ROI)
Astros Best Bets Today:
The Houston Astros have hit the 1st Five Innings (F5) Team Total Over in 17 of their last 24 games (+9.80 Units / 36% ROI)
The Houston Astros have hit the Game Total Over in 13 of their last 18 games (+7.20 Units / 35% ROI)
The Houston Astros have hit the Moneyline in 7 of their last 8 games at home (+5.70 Units / 49% ROI)
The Houston Astros have covered the Run Line in 6 of their last 8 games at home (+5.40 Units / 60% ROI)
The Houston Astros have hit the Team Total Over in 12 of their last 18 games at home (+5.40 Units / 25% ROI)
Cardinals Against the Spread (ATS) Record
Against the spread this season, the Cardinals are 9-8 against the Run Line (-2.3 Units / -8.93% ROI).
10-8 when betting on the Moneyline for +3.15 Units / 16.94% ROI
10-7 when betting on the total runs Over for +2.4 Units / 12.31% ROI
7-10 when betting on the total runs Under for -4.3 Units / -21.29% ROI
Astros Against the Spread (ATS) Record
Against the spread this season, the Astros are 8-12 against the Run Line (-3.85 Units / -16.45% ROI).
8-12 when betting on the Moneyline for -7.75 Units / -28.44% ROI
13-7 when betting on the total runs Over for +4.9 Units / 21.63% ROI
7-13 when betting on the total runs Under for -7.05 Units / -33.02% ROI
Astros vs Cardinals Home Run Prop Bets Today
Yes
Yordan Alvarez
Christian Walker
Nolan Gorman
Jordan Walker
Alec Burleson
Astros vs Cardinals Total Hits Prop Bets Today
Astros vs Cardinals Strikeout Prop Bets Today
Cardinals Keys to the Game vs. the Astros
The Cardinals were just 7-11 (.389) when tied entering the 8th inning in the 2025 season — tied for 5th lowest in MLB; League Avg: .500.
The Cardinals are 70-4 (.946) when leading entering the 8th inning since the 2025 season — 5th best in MLB; League Avg: .907.
The Cardinals are 29-18 (.617) when tied entering the 7th inning since the 2024 season — 3rd best in MLB; League Avg: .499.
The Cardinals are 148-5 (.967) when leading entering the 9th inning since the 2024 season — 5th best in MLB; League Avg: .952.
Astros Keys to the Game vs. the Cardinals
The Astros are just 0-10 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .050.
The Astros are just 0-10 (.000) when trailing entering the 7th inning this season — tied for lowest in MLB; League Avg: .134.
The Astros were 56-7 (.889) when they scored 5 or more runs in the 2025 season — 3rd best in MLB; League Avg: .797.
The Astros are 7-3 (.700) at home this season — tied for 5th best in MLB; League Avg: .565.
Cardinals Hitting Stats & Trends
Cardinals hitters had an OPS of just .941 (1,172 PA’s) when the pitcher was behind in the count in the 2025 season — 2nd lowest in MLB.
Cardinals hitters slugged just .489 when the pitcher was behind in the count in the 2025 season — 2nd lowest in MLB.
The Cardinals are batting just .157 when facing the starting pitcher for the 3rd time in a game this season — 2nd lowest in MLB.
The Cardinals are batting just .215 with two outs since the 2025 season — lowest in MLB.
Astros Hitting Stats & Trends
Astros hitters are slugging .871 in lefty-lefty matchups this season — best in MLB.
Astros hitters have an OPS of .932 (147 PA’s) in lefty-lefty matchups since the 2025 season — best in MLB.
The Astros are batting .419 in lefty-lefty matchups this season — best in MLB.
Astros hitters have an OPS of 1.371 (38 PA’s) in lefty-lefty matchups this season — best in MLB.
Cardinals Pitching Stats & Trends
Opponents have a miss rate of just 19% against Cardinals pitchers this season — lowest in MLB.
Cardinals pitchers have a strikeout rate of just 31% with two-strikes this season — lowest in MLB.
Cardinals pitchers have a strikeout rate of just 15% this season — lowest in MLB.
Cardinals pitchers have a strikeout rate of just 14% with runners in scoring position this season — lowest in MLB.
Astros Pitching Stats & Trends
Astros pitchers have walked 14% of batters this season — highest in MLB.
The Astros have allowed 4.25 runs per game (85/20) in the first 5 innings this season — highest in MLB.
Astros pitchers have an ERA of 6.01 (172.1 IP) this season — highest in MLB.
The Astros have allowed 7.50 runs per game (75/10) on the road this season — highest in MLB.
More MLB Reading:
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