Bryan Armetta breaks down his three favorite MLB bets today on DraftKings Sportsbook for Saturday’s 15-game slate.

Another day, another jam-packed MLB slate. 15 games between 30 teams make up Saturday’s action on the diamond. Among the matchups to watch, Tigers ace Tarik Skubal will battle the Red Sox at Fenway Park. Later, division rivals will clash when the Rangers take on the Mariners. Elsewhere, Chris Sale’s Braves take on Cristopher Sanchez’s Phillies for an NL East showdown.

With so many matchups on deck, the options are endless for bettors. Before the start of Saturday’s contests, here are three MLB bets worth placing on DraftKings Sportsbook.

It’s a matchup between All-Stars on the mound in Miami. For the home team, it’ll be none other than Sandy Alcantara toeing the slab. The former Cy Young winner hit a speed bump during his last time out, coughing up seven runs against the Tigers. With that being said, it’s been a stellar 2026 campaign for the righty. Prior to his blow-up vs. Detroit, Alcantara gave up just two earned runs over 23.1 innings of work (0.77 ERA). To boot, his bad outing last Sunday came on the road. LoanDepot Park is the perfect pitcher-friendly venue for a bounce back.

Granted, Alcantara isn’t the only big-time arm in action this evening. Brandon Woodruff, when healthy, is a stellar pitcher. With that being said, the Marlins might have an edge tonight against the 33-year-old. Other than the fastball, Woodruff’s favorite pitches are the sinker (21%) and changeup (20%). As a unit, Miami owns a combined .283 batting average against those offerings in 2026. The Fish are scoring the ninth-most runs per game at home this season (5.09). In comparison, the Brewers are missing key hitters such as Christian Yelich (groin), Jackson Chourio (hand) and Andrew Vaughn (hand).

The Astros have gotten off to a rocky start, posting a 8-12 record. With that being said, they’ve been effective when it comes to putting up runs. Houston ranks second in the American League with 5.29 runs scored per game. The headliner is Yordan Alvarez, who leads the majors with eight home runs, 19 RBIs and a 1.229 OPS. That’s bad news for tonight’s starter, Andre Pallante. St. Louis’ right-hander is the definition of ‘meh’ on the mound. He currently owns a lackluster 6.00 expected ERA per Savant. In addition, the fifth-year pro has surrendered 9.2 hits per nine innings throughout his career. In comparison, the ‘Stros are third in baseball with a .262 batting average.

Pallante isn’t the only questionable pitcher in action tonight. Lance McCullers Jr. has been a staple for the Astros over the past decade. However, it’s clear that the 32-year-old’s best days are behind him. Since the 2025 season, the veteran has notched a dismal 6.37 ERA and 1.70 WHIP. The Cardinals aren’t at Houston’s level on offense, but they aren’t pushovers either. St. Louis is averaging 4.68 runs per game, 11th-most in the league this season. On paper, it’s difficult to back either of these starters at the moment.

At 11-10, the Angels have been surprisingly competitive through the first portion of the season. Granted, it’s early; the odds are against a postseason push for the Halos. Still, it’s hard not to be impressed by this group over the past week. Following a hard-fought series split on the road against the Yankees, they dominated San Diego on Friday for an 8-0 victory. Los Angeles will attempt to earn a series win this evening with staff ace Yusei Kikuchi on the bump. It’s been a terrible first few weeks for the former All-Star. Over 18.0 innings, he owns a 7.50 ERA and 1.89 WHIP. However, three of his four appearances have come on the road. Kikuchi was a much better pitcher at home (2.93 ERA) than on the road (5.04 ERA) last season.

It’s not as if LA will be facing an elite hurler on offense. San Diego will turn to German Marquez on Saturday, making his fourth appearance of the year. The former Rockies All-Star is far removed from his glory days. Over 13.0 innings, he’s on the hook for a 5.54 ERA and 1.69 WHIP. Even more concerning, he’s allowing a whopping 3.5 home runs per nine innings. On the flip side, Los Angeles ranks second in baseball with 34 homers this season. With an advantage on the mound at home, I’ll gladly back the Angels in what is essentially a pick ’em.