The Diamondbacks are -160 favorites vs the White Sox

White Sox vs Diamondbacks Over / Under today: 9 Runs

White Sox / Diamondbacks TV Channel: CHSN | DBTV

The Chicago White Sox (+135) visit Chase Field to take on the Arizona Diamondbacks (-160) on April 21, 2026. First pitch is scheduled for 9:40 pm in Phoenix, AZ.

This season, the White Sox are 8-14 against the spread (ATS), while the Diamondbacks are 17-5 ATS.

White Sox vs Diamondbacks Starting Pitchers Today:

White Sox starting pitcher: Sean Burke 0-2, 4.43 ERA

Diamondbacks starting pitcher: Merrill Kelly 1-0, 3.38 ERA

White Sox vs. Diamondbacks Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneylineWhite Sox+1.5 -165O 9 +100+135Diamondbacks -1.5 +135U 9 -120-160

Based on recent trends the model predicts the Diamondbacks will win Tuesday‘s MLB game with 57.6% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on White Sox vs Diamondbacks and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for White Sox players for Tuesday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Bets Today:

Munetaka Murakami has hit the Home Runs Over in 4 of his last 6 games (+14.00 Units / 233% ROI)

Edgar Quero has hit the Runs Under in his last 10 games (+10.00 Units / 44% ROI)

Colson Montgomery has hit the Singles Under in 13 of his last 15 games (+8.75 Units / 33% ROI)

Miguel Vargas has hit the Walks Over in 14 of his last 25 games (+8.70 Units / 35% ROI)

Chase Meidroth has hit the Hits Under in 12 of his last 20 away games (+7.60 Units / 28% ROI)

And here are some favorite MLB player prop bets for Diamondbacks players for Tuesday‘s game, looking at profitable historical betting trends:

Best Diamondbacks Player Prop Best Bets Today:

Ildemaro Vargas has hit the Hits Over in his last 15 games (+15.00 Units / 52% ROI)

Alek Thomas has hit the Singles Under in 17 of his last 20 games (+12.65 Units / 40% ROI)

Ildemaro Vargas has hit the Runs Over in 8 of his last 10 games (+10.65 Units / 107% ROI)

Jose Fernandez has hit the Home Runs Over in 1 of his last 7 games at home (+10.00 Units / 143% ROI)

Ildemaro Vargas has hit the Total Bases Over in 11 of his last 15 games (+8.95 Units / 45% ROI)

White Sox Best Bets Today:

The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Over in 31 of their last 50 away games (+8.20 Units / 13% ROI)

The Chicago White Sox have hit the 1st Five Innings (F5) Moneyline in 14 of their last 25 games (+6.70 Units / 26% ROI)

The Chicago White Sox have hit the Game Total Over in 16 of their last 25 games (+6.10 Units / 22% ROI)

The Chicago White Sox have hit the Team Total Over in 29 of their last 50 away games (+6.00 Units / 10% ROI)

The Chicago White Sox have hit the Moneyline in 23 of their last 50 away games (+4.10 Units / 8% ROI)

Diamondbacks Best Bets Today:

The Arizona Diamondbacks have hit the Team Total Over in 34 of their last 50 games (+17.90 Units / 32% ROI)

The Arizona Diamondbacks have covered the Run Line in 34 of their last 50 games (+12.70 Units / 18% ROI)

The Arizona Diamondbacks have hit the 1st Five Innings (F5) Moneyline in 26 of their last 45 games at home (+11.90 Units / 20% ROI)

The Arizona Diamondbacks have hit the Moneyline in 23 of their last 35 games at home (+10.40 Units / 24% ROI)

The Arizona Diamondbacks have hit the 1st Five Innings (F5) Team Total Under in 15 of their last 20 games at home (+9.10 Units / 37% ROI)

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 10-12 against the Run Line (-7.95 Units / -24.96% ROI).

8-14 when betting on the Moneyline for -2.8 Units / -12.67% ROI

14-8 when betting on the total runs Over for +5.1 Units / 21.07% ROI

8-14 when betting on the total runs Under for -7.5 Units / -30.99% ROI

Diamondbacks Against the Spread (ATS) Record

Against the spread this season, the Diamondbacks are 17-5 against the Run Line (+10.15 Units / 31.47% ROI).

13-9 when betting on the Moneyline for +6.05 Units / 25.53% ROI

13-8 when betting on the total runs Over for +4.3 Units / 17.62% ROI

8-13 when betting on the total runs Under for -6 Units / -25% ROI

Diamondbacks vs White Sox Home Run Prop Bets Today

Yes

Munetaka Murakami

+310

Ketel Marte

+375

Corbin Carroll

+425

Colson Montgomery

+425

Adrian Del Castillo

+550

Diamondbacks vs White Sox Total Hits Prop Bets Today

Diamondbacks vs White Sox Strikeout Prop Bets Today

White Sox Keys to the Game vs. the Diamondbacks

The White Sox are just 87-41 (.680) when leading entering the 7th inning since the 2024 season — lowest in MLB; League Avg: .866.

The White Sox are just 54-18 (.750) when leading entering the 7th inning since the 2025 season — lowest in MLB; League Avg: .874.

The White Sox are just 62-7 (.899) when leading entering the 9th inning since the 2025 season — lowest in MLB; League Avg: .955.

The White Sox are just 11-105 (.095) when allowing 10 or more hits since the 2024 season — lowest in MLB; League Avg: .251.

Diamondbacks Keys to the Game vs. the White Sox

The Diamondbacks are 3-4 (.429) when trailing entering the 7th inning this season — best in MLB; League Avg: .133.

The Diamondbacks are just 69-20 (.775) when leading entering the 7th inning since the 2025 season — 2nd lowest in MLB; League Avg: .874.

The Diamondbacks were just 67-7 (.905) when leading entering the 9th inning in the 2025 season — 2nd lowest in MLB; League Avg: .956.

The Diamondbacks are 2-5 (.286) when trailing entering the 8th inning this season — tied for best in MLB; League Avg: .107.

White Sox Hitting Stats & Trends

The White Sox have a winning percentage of just 32% since the 2024 season — lowest in MLB.

The White Sox won only 33% of their road games in the 2025 season — tied for 2nd lowest in MLB.

White Sox hitters have an OPS of just .510 (251 PA’s) in innings 7-9 this season — lowest in MLB.

The White Sox have a winning percentage of just 29% on the road since the 2024 season — 2nd lowest in MLB.

Diamondbacks Hitting Stats & Trends

The Diamondbacks are batting .270 against LHP since the 2024 season — best in MLB.

Diamondbacks hitters have chased 49% of pitches out of the zone with two-strikes this season — highest in MLB.

Diamondbacks hitters struck out in just 19% of their PA’s against LHP in the 2025 season — 3rd best in MLB.

The Diamondbacks are batting .284 against LHP this season — tied for 2nd best in MLB.

White Sox Pitching Stats & Trends

The White Sox have won just 15% of games in which their opponents scored first since the 2024 season — lowest in MLB.

Opponents have a miss rate of just 22% against White Sox pitchers this season — 2nd lowest in MLB.

The White Sox have won just 9% of road games in which their opponents scored first since the 2024 season — lowest in MLB.

In games when their opponents have scored three or more runs in an inning, the White Sox won just 10% of the time since the 2024 season — lowest in MLB.

Diamondbacks Pitching Stats & Trends

Diamondbacks pitchers have allowed an OBP of just .250 (196 PA’s) when facing the leadoff batter in the inning this season — 2nd best in MLB.

Diamondbacks pitchers have walked 8% of batters this season — 5th best in MLB.

Diamondbacks pitchers have a strikeout rate of just 20% this season — tied for 4th lowest in MLB.

Diamondbacks pitchers have walked 4% of batters when facing the leadoff batter in the inning this season — best in MLB.

More MLB Reading:

Bet now on White Sox vs Diamondbacks and all games with BetMGM

Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.