April 21, 2026, 10:35 a.m. ET
The Toronto Blue Jays (9-13) and Los Angeles Angels (11-13) play the second game of their 3-game series Tuesday in Anaheim, California. First pitch from Angel Stadium is 9:38 p.m. ET. Let’s analyze MLB odds around the Blue Jays vs. Angels odds and make our expert MLB picks and predictions for the best bets.
Season series: Blue Jays lead 1-0
After a 4-game losing streak the Blue Jays have won 2 games in a row. They took the series opener 5-2 Monday. SP Dylan Cease struck out 12 in 5 innings (5 H, 2 ER, 2 BB) and got his first win of the year. The bullpen threw 4 scoreless frames with RP Jeff Hoffman striking out the side in the ninth for his third save. 1B Vladimir Guerrero went 3 for 4 with his second HR and drove in 2.
The Angels have lost 3 games in a row and are 1-3 so far on their homestand. SP Reid Detmers (6 IP, 5 H, 4 ER, 2 BB, 5 K) took the loss. The offense had only 6 hits, only 1 after the fifth inning.
Watch MLB on Fubo!Blue Jays at Angels projected starters
LHP Patrick Corbin vs. RHP Jack Kochanowicz
Corbin (0-0, 4.66 ERA) makes his third start. He has a 1.24 WHIP, 2 BB and 9 K in 9 2/3 innings.
Last start: No-decision, 5 2/3 IP, 1 ER, 4 H, 1 BB, 6 K in a 2-1 road loss to the Milwaukee Brewers ThursdayCareer vs. Angels: 4-0, 3.52 ERA (38 1/3 IP, 15 ER), 1.38 WHIP, 9.2 K/9 in 7 starts2026 road splits: 0-0, 1.59 ERA (5 2/3 IP, 1 ER) 0.88 WHIP, 6 K in 1 start
Kochanowicz (2-0, 3.47 ERA) makes his fifth start. He has a 1.24 WHIP, 5.8 BB/9 and 6.9 K/9 in 23 1/3 innings.
Last start: No-decision, 6 2/3 IP, 3 ER, 4 H, 4 BB, 6 K in a 5-4 road loss to the New York Mets WednesdayCareer vs. Blue Jays: 0-0, 4.76 ERA (11 1/3 IP, 6 ER), 1.32 WHIP, 1.6 K/9 in 2 starts2026 home splits: 1-0, 0.00 ERA (5 2/3 IP, 0 ER), 1.06 WHIP, 7 K in 1 startBlue Jays at Angels odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:24 a.m. ET.
Moneyline (ML): Blue Jays -102 (bet $102 to win $100) | Angels -118 (bet $118 to win $100)Run line (RL)/Against the spread (ATS): Blue Jays -1.5 (+150) | Angels +1.5 (-200)Over/Under (O/U): 9 (O: -120 | U: +100)
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Blue Jays at Angels picks and predictionsPrediction
Angels 7, Blue Jays 4
The Blue Jays, despite winning their last 2 away games, are only 3-7 on the road. The Angels have lost 3 straight at home and 5 of their last 6 in Anaheim.
Kochanowicz has had 2 straight quality starts, and the one before that, he didn’t allow a run in 5 2/3 innings. The Angels have not lost 4 consecutive games yet this season.
BET ANGELS (-118).
Expecting the home team to win, betting them +1.5 (-200) doesn’t give you the value betting them to win outright does. However, 9 of the Blue Jays’ 13 losses have been by multiple runs, and 9 of the Angels’ wins have been by 2 or more runs, so you can make even more money betting ANGELS ALTERNATE SPREAD -1.5 (+165).
Two of Kochanowicz’s starts have had totals over 9 total runs. One of Corbin’s 2 starts has had a double-digit total.
The Angels have scored 4 combined runs in their last 3 games. Since April 5, the 3-game streak of games with totals under 10 is the longest streak they have had.
BET OVER 9 (-120).
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