CLEVELAND — The reigning American League Central Division champion Cleveland Guardians will conclude their three-game series with the Houston Astros on Wednesday, April 22.
The Guardians won 8-5 on Tuesday, April 21 to even the series after the Astros won 9-2 on Monday, April 20.
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The Guardians (14-11) remain in first place in the American League Central Division and the Astros (9-16) are at the bottom of the AL West standings.
Follow our live updates throughout the game tonight. Here’s what to know before the first pitch:
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Cleveland Guardians home series vs. Houston Astros
Apr 20, 2026; Cleveland, Ohio, USA; Cleveland Guardians starting pitcher Slade Cecconi (44) throws a pitch against the Houston Astros during the first inning at Progressive Field. Mandatory Credit: Ken Blaze-Imagn Images
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Cleveland Guardians home series vs. Houston Astros
Apr 20, 2026; Cleveland, Ohio, USA; Cleveland Guardians starting pitcher Slade Cecconi (44) throws a pitch against the Houston Astros during the first inning at Progressive Field. Mandatory Credit: Ken Blaze-Imagn Images
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Cleveland Guardians home series vs. Houston Astros
Apr 20, 2026; Cleveland, Ohio, USA; Houston Astros first baseman Christian Walker (8) rounds the bases after hitting a home run against the Cleveland Guardians during the first inning at Progressive Field. Mandatory Credit: Ken Blaze-Imagn Images
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Cleveland Guardians home series vs. Houston Astros
Apr 20, 2026; Cleveland, Ohio, USA; Houston Astros starting pitcher Spencer Arrighetti (41) throws a pitch against the Cleveland Guardians during the first inning at Progressive Field. Mandatory Credit: Ken Blaze-Imagn Images
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Cleveland Guardians home series vs. Houston Astros
Apr 20, 2026; Cleveland, Ohio, USA; Cleveland Guardians first baseman Kyle Manzardo (9) hits a single during the first inning against the Houston Astros at Progressive Field. Mandatory Credit: Ken Blaze-Imagn Images
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Cleveland Guardians home series vs. Houston Astros
Apr 20, 2026; Cleveland, Ohio, USA; Cleveland Guardians third baseman Jose Ramirez (11) celebrates after scoring against the Houston Astros during the first inning at Progressive Field. Mandatory Credit: Ken Blaze-Imagn Images
When do the Guardians play today?
First pitch is 1:10 p.m. Wednesday, April 22.
Guardians designated hitter Chase DeLauter hits an RBI triple during the eighth inning against the Houston Astros, April 21, 2026, in Cleveland.
More MLB coverage: Chase DeLauter snaps his skid, wins game for Guardians vs Astros
Where to watch Guardians game today?
The Cleveland Guardians vs. Houston Astros game is available on TV via Guardians.TV and Space City Home Network. Streaming is available on MLB.TV and Fubo, which offers a free trial.
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Guardians lineup today vs. Astros
Apr 21, 2026; Cleveland, Ohio, USA; Cleveland Guardians left fielder Angel Martinez (1) celebrates after hitting a home run during the second inning against the Houston Astros at Progressive Field. Mandatory Credit: Ken Blaze-Imagn Images
Astros lineup today vs. Guardians
Guardians starting pitcher Tanner Bibee throws a first-inning pitch against the Baltimore Orioles, April 17, 2026, in Cleveland.
Guardians vs. Astros starting pitchers
The Guardians will send right-hander Tanner Bibee (0-2, 4.81 ERA) to the mound and the Astros will counter with right-hander Peter Lambert (0-1, 7.20 ERA).
More MLB coverage: Former Akron Zips pitcher Chris Bassitt keeps showing he’s a competitor for the Baltimore Orioles
Steven Kwan, left, and Angel Martinez, middle, and Brayan Rocchio celebrate after scoring on a triple by Guardians DH Chase DeLauter (not pictured) during the eighth inning against the Houston Astros, April 21, 2026, in Cleveland.
American League Central Division standings
More MLB coverage: Guardians display strength up the middle of diamond against Orioles
Apr 21, 2026; Cleveland, Ohio, USA; Cleveland Guardians right fielder George Valera (7) hits an RBI single during the first inning against the Houston Astros at Progressive Field. Mandatory Credit: Ken Blaze-Imagn Images
Guardians vs. Blue Jays pitching probables
Akron Beacon Journal sports writer Michael Beaven can be reached by email at mbeaven@thebeaconjournal.
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This article originally appeared on Akron Beacon Journal: Cleveland Guardians lineup today, score, live updates vs. Astros