The Giants’ 12-2 loss to the Arizona Diamondbacks on Monday at Chase Field was ugly in more ways than one.

Not only did their NL West opponents blow them out in the series opener, but the Giants also lost two starting position players to injuries during the game.

First, Jung Hoo Lee was replaced in right field by Will Brennan before the bottom of the fourth inning after he left with what the Giants later announced as back spasms (h/t the San Francisco Chronicle’s Shayna Rubin).

Then, shortstop Willy Adames was pinch-hit for in the top of the sixth after a ground ball struck him in the finger during the previous inning on an error which allowed Arizona’s 12th run to score.

Jesús Rodríguez is on deck to pinch-hit for Willy Adames.

Adames kept shaking his hand after committing this error. pic.twitter.com/V2iJTMQmEg

— Justice delos Santos (@justdelossantos) May 19, 2026

After the game, Giants manager Tony Vitello shared what the next couple of days could look like for both players.

“Kind of tough to tell [the severity of Lee’s injury],” Vitello told reporters after the game. “Definitely cautionary in the middle of the game, but then take a look, and then it’s a completely different set of circumstances. But similar to [Heliot] Ramos, just to call in an example, get through the night, and then follow up tomorrow and take a closer look, and and see what’s going on there … But probably [Lee will be] down for tomorrow, and a day where can fully assess what’s going on, see if it’s worse or better.”

Lee was 1-for-2 with a single before he came out of the game. Adames, meanwhile, gave San Francisco its first run in the second inning with a solo home run to left field — his fourth of the 2026 MLB season.

Unlike Lee, Vitello wasn’t sure if Adames will miss Tuesday’s game and shared the Giants will “see where it’s at” as far as his unlucky injury goes.

“The ball was real well struck, [Adames] doesn’t see it because it’s in front of the runner, jumped up on him, and just nicked his thumb,” Vitello told reporters. “But when I say nick, it’s a baseball, and it was hit whatever the velocity was you guys got. So a little bit of a contusion there, and I think probably as good of news as you want from that. Ideally it doesn’t happen, but again, I think as good of news from that, but that was why he came out of the game.”

The Giants already are short one outfielder after placing Heliot Ramos on the 10-day injured list with a right quadriceps strain. Starting pitcher Logan Webb also is on the IL with a knee injury, but he’s scheduled to make a rehab appearance later this week and should be back in the rotation soon.

San Francisco went to Arizona seeking its third consecutive victory after winning the weekend’s series against the Athletics. But instead, they suffered a brutal loss — and two more injuries as a team that certainly can’t afford any setbacks.

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