Interleague baseball heads to Wrigley Field on Friday afternoon as the Houston Astros and Chicago Cubs open a three-game series.

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May 19, 2026; Minneapolis, Minnesota, USA; Houston Astros third baseman Isaac Paredes (15) celebrates hitting a two run home run against the Minnesota Twins in the first inning at Target Field. Mandatory Credit: Jesse Johnson-Imagn Images

How to Watch Astros vs Cubs

Date: Friday, May 22, 2026

Time: 2:20 PM ET

Channel: Apple TV

Stream: Apple TV (try for free)

Chicago enters the weekend as one of the National League’s stronger early-season teams at 27-14, leaning on a balanced offense and strong home play at Wrigley Field.

Ian Happ and Nico Hoerner continue to pace the lineup, while the Cubs are expected to hand the ball to Jameson Taillon, who looks to rebound after a difficult last outing. Chicago has built much of its success on consistent offense and strong pitching depth, helping keep the club near the top of the NL Central entering late May.

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Houston arrives trying to reverse a difficult opening stretch after injuries and offensive inconsistency slowed momentum early in the season. The Astros are expected to counter with Spencer Arrighetti (5-1, 1.50 ERA), who has quietly become one of Houston’s biggest bright spots after allowing one run or fewer in five of his six starts entering Friday.

Yordan Alvarez remains the centerpiece of Houston’s lineup, leading the club in several major offensive categories, while the Astros hope a strong series in Chicago can begin building momentum heading into summer. First pitch is scheduled for 2:20 p.m. ET Friday at Wrigley Field, with the game streaming nationally on Apple TV+.

This is a great MLB matchup that you will not want to miss; make sure to tune in and catch all the action.

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