The Cardinals are -145 favorites vs the Diamondbacks

Diamondbacks vs Cardinals Over / Under today: 8.5 Runs

Diamondbacks / Cardinals TV Channel: CATV | DBTV

The Arizona Diamondbacks (+120) visit Busch Stadium to take on the St. Louis Cardinals (-145) on June 22, 2026. First pitch is scheduled for 7:45 pm in St. Louis, MO.

This season, the Diamondbacks are 39-38 against the spread (ATS), while the Cardinals are 46-28 ATS.

Diamondbacks vs Cardinals Starting Pitchers Today:

Diamondbacks starting pitcher: Merrill Kelly 5-6, 5.85 ERA

Cardinals starting pitcher: Andre Pallante 8-4, 3.76 ERA

Diamondbacks vs. Cardinals Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneylineDiamondbacks+1.5 -175O 8.5 -110+120Cardinals -1.5 +145U 8.5 -110-145

Based on recent trends the model predicts the Cardinals will win Monday‘s MLB game with 56.4% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

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We’ve highlighted some favorite MLB player prop bets for Diamondbacks players for Monday‘s game, looking at profitable historical betting trends:

Best Diamondbacks Player Prop Bets Today:

Gabriel Moreno has hit the Home Runs Over in 3 of his last 10 away games (+19.30 Units / 193% ROI)

Nolan Arenado has hit the RBIs Under in 21 of his last 25 games (+13.35 Units / 25% ROI)

Nolan Arenado has hit the Total Bases Under in 19 of his last 25 games (+12.10 Units / 32% ROI)

Ketel Marte has hit the Runs Under in 15 of his last 20 away games (+10.40 Units / 43% ROI)

Jorge Barrosa has hit the Singles Under in 19 of his last 25 games (+9.80 Units / 24% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Monday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

Alec Burleson has hit the RBIs Over in 14 of his last 20 games (+15.70 Units / 79% ROI)

Alec Burleson has hit the Singles Over in 16 of his last 20 games at home (+10.90 Units / 42% ROI)

Ivan Herrera has hit the Total Bases Under in 19 of his last 25 games (+10.55 Units / 27% ROI)

Masyn Winn has hit the Runs Over in 8 of his last 10 games (+9.90 Units / 99% ROI)

Jordan Walker has hit the Hits Over in 11 of his last 15 games (+8.75 Units / 35% ROI)

Diamondbacks Best Bets Today:

The Arizona Diamondbacks have hit the 1st Five Innings (F5) Team Total Under in 36 of their last 50 games (+21.45 Units / 36% ROI)

The Arizona Diamondbacks have hit the Game Total Under in 28 of their last 45 games (+12.85 Units / 26% ROI)

The Arizona Diamondbacks have hit the Team Total Over in 31 of their last 50 away games (+9.95 Units / 17% ROI)

The Arizona Diamondbacks have covered the Run Line in 18 of their last 35 games (+1.70 Units / 4% ROI)

The Arizona Diamondbacks have hit the 1st Five Innings (F5) Moneyline in 3 of their last 5 games (+0.80 Units / 11% ROI)

Cardinals Best Bets Today:

The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 32 of their last 50 games (+11.40 Units / 19% ROI)

The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Over in 15 of their last 19 games (+11.35 Units / 50% ROI)

The St. Louis Cardinals have covered the Run Line in 32 of their last 50 games (+10.45 Units / 15% ROI)

The St. Louis Cardinals have hit the Team Total Over in 14 of their last 19 games (+8.60 Units / 38% ROI)

The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 25 of their last 50 games (+8.15 Units / 15% ROI)

Diamondbacks Against the Spread (ATS) Record

Against the spread this season, the Diamondbacks are 43-33 against the Run Line (+4.75 Units / 4.6% ROI).

39-38 when betting on the Moneyline for -1.05 Units / -1.14% ROI

33-40 when betting on the total runs Over for -10.75 Units / -12.65% ROI

40-33 when betting on the total runs Under for +4.1 Units / 4.85% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 46-28 against the Run Line (+10 Units / 9.32% ROI).

41-34 when betting on the Moneyline for +11.05 Units / 13.85% ROI

34-37 when betting on the total runs Over for -6.4 Units / -7.8% ROI

37-34 when betting on the total runs Under for -0.65 Units / -0.78% ROI

Cardinals vs Diamondbacks Home Run Prop Bets Today

Cardinals vs Diamondbacks Total Hits Prop Bets Today

Cardinals vs Diamondbacks Strikeout Prop Bets Today

Diamondbacks Keys to the Game vs. the Cardinals

The Diamondbacks are just 87-23 (.791) when leading entering the 7th inning since the 2025 season — tied for lowest in MLB; League Avg: .870.

The Diamondbacks are just 98-16 (.860) when leading entering the 8th inning since the 2025 season — tied for 2nd lowest in MLB; League Avg: .905.

The Diamondbacks are 7-97 (.067) when trailing entering the 9th inning since the 2025 season — tied for 4th best in MLB; League Avg: .047.

The Diamondbacks were just 67-7 (.905) when leading entering the 9th inning in the 2025 season — 2nd lowest in MLB; League Avg: .956.

Cardinals Keys to the Game vs. the Diamondbacks

The Cardinals are just 10-95 (.095) when trailing entering the 7th inning since the 2025 season — 5th lowest in MLB; League Avg: .129.

The Cardinals were 69-1 (.986) when leading entering the 9th inning in the 2024 season — tied for 2nd best in MLB; League Avg: .949.

The Cardinals are 160-11 (.936) when leading entering the 8th inning since the 2024 season — tied for 5th best in MLB; League Avg: .903.

The Cardinals were 18-9 (.667) when tied entering the 7th inning in the 2024 season — tied for 3rd best in MLB; League Avg: .498.

Diamondbacks Hitting Stats & Trends

Diamondbacks hitters have struck out in just 16% of their PA’s against LHP this season — best in MLB.

The Diamondbacks are batting .331 in lefty-lefty matchups this season — best in MLB.

The Diamondbacks are batting .268 against LHP this season — tied for 2nd best in MLB.

9% of Diamondbacks’ hitters plate appearances have lasted only one pitch (265/2,866 PA’s) this season — lowest in MLB.

Cardinals Hitting Stats & Trends

Cardinals hitters have struck out in just 17% of their PA’s against LHP this season — 2nd best in MLB.

The Cardinals are batting .179 on pitches out of the zone this season — 5th best in MLB.

Cardinals hitters have put 41% of their swings in play against LHP this season — 2nd highest in MLB.

Cardinals hitters have an OBP of .330 (1,472 PA’s) on the road this season — tied for 4th best in MLB.

Diamondbacks Pitching Stats & Trends

Diamondbacks pitchers have a strikeout rate of just 18% this season — 2nd lowest in MLB.

Opponents have a miss rate of just 23% against Diamondbacks pitchers this season — 3rd lowest in MLB.

Diamondbacks pitchers have walked 8% of batters this season — tied for 5th best in MLB.

Diamondbacks pitchers have walked 7% of batters when facing the leadoff batter in the inning this season — 4th best in MLB.

Cardinals Pitching Stats & Trends

Opponents have a miss rate of just 23% against Cardinals pitchers this season — 2nd lowest in MLB.

The Cardinals pitchers have allowed an average Exit Velocity of 90.3 MPH this season (1,965 balls in play) — highest in MLB

Cardinals pitchers have a strikeout rate of just 18% with runners in scoring position this season — lowest in MLB.

Cardinals pitchers have a strikeout rate of just 20% this season — 5th lowest in MLB.

More MLB Reading:

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