The Detroit Tigers (38-21) and Chicago White Sox (31-28) begin a 3-game series Monday. First pitch from Rate Field is set for 7:40 p.m. ET. Let’s analyze BetMGM Sportsbook’s MLB odds around the Tigers vs. White Sox odds and make our expert MLB picks and predictions for the best bets.

Season series: Tigers lead 3-0

The Tigers edged the Royals 1-0 Sunday, cashing as +140 underdogs with the Under (8.5) hitting. Detroit has now won back-to-back series and continues to dominate on the mound, allowing just 1.5 runs per game over its last 7 contests. The Tigers hold the best record in MLB.

The White Sox dropped Sunday’s game 3-2, getting swept in a 3-game series at the Baltimore Orioles. They fell as +125 road underdogs with the Under (9) hitting. Chicago has now lost 6 of its last 7 games and sits with a -52 run differential on the season.

Tigers at White Sox projected starters

RHP Jack Flaherty vs. RHP Jonathan Cannon

Flaherty (3-6, 3.94 ERA) is making his 12th start. He has a 1.11 WHIP, 2.9 BB/9 and 10.9 K/9 in 59 1/3 innings.

Last start: Win, 6 IP, 0 ER, 2 H, 1 BB, 8 K in 3-1 home victory against San Francisco Giants Tuesday2025 road stats: 1-3, 5.06 ERA (26 2/3 IP, 15 ER), 1.31 WHIP, 9.1 K/9 in 5 startsLast start vs. White Sox: Win, 5 2/3 IP, 1 ER, 3 H, 2 BB, 7 K in 7-4 home victory April 4Career vs. White Sox: 2-1, 2.57 ERA (21 IP, 6 ER), 18 H, 6 BB, 25 K in 4 starts

Cannon (2-6, 4.15 ERA) is making his 10th start and 12th appearance. He has a 1.35 WHIP, 2.7 BB/9 and 6.8 K/9 in 60 2/3 innings.

Last start: Loss, 5 2/3 IP, 5 ER, 9 H, 1 BB, 4 K in 6-4 road loss against New York Mets Tuesday2025 home stats: 1-0, 1.17 ERA (15 1/3 IP, 2 ER), 16 H, 5 BB, 14 K in 3 startsLast start vs. Tigers: Loss, 3 2/3 IP, 3 ER, 3 H, 3 BB, 3 K in 7-4 road loss April 4Career vs. Tigers: 1-3, 11.20 ERA (13 2/3 IP, 17 ER), 22 H, 10 BB, 11 K in 4 starts

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Tigers at White Sox odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:40 a.m. ET.

Moneyline (ML): Tigers -210 (bet $210 to win $100) | White Sox +170 (bet $100 to win $170)Run line (RL)/Against the spread (ATS): Tigers -1.5 (-125) | White Sox +1.5 (+105)Over/Under (O/U): 8 (O: -115 | U: -105)Tigers at White Sox picks and predictionsPrediction

Detroit 5, White Sox 2

PASS.

The Tigers (-210) will win Monday, but I can’t bet 2.1 units to win 1 back. I’ll take my wager to the run line.

BET TIGERS -1.5 (-125).

It’s hard to ignore the value in backing the Tigers Monday, even if it feels a little too obvious. Detroit enters with the best record in MLB and has allowed just 11 total runs over its last 7 games, winning 6 of them. It has also won 9 of its last 12 on the road.

Meanwhile, the White Sox sit at the bottom of the AL Central, with a 12-15 home record and a .220 team batting average at Rate Field. Detroit outscored Chicago 18-9 in a 3-game sweep earlier this season and should have the edge again in the opener. Tigers OF Kerry Carpenter is 4-for-7 with 2 home runs and 5 RBIs in his career against Cannon. 2B Colt Keith also owns 4 hits in 7 at-bats with a homer and 4 RBIs. On the flip side, Chicago’s lineup is hitting just .151 lifetime against Flaherty.

Back the Tigers to cruise.

BET UNDER 8 (-105).

The Under is worth a look Monday, with both teams trending in that direction. The Tigers have hit the Under in 8 of their last 10, fueled by strong pitching. The Under is also 3-1-1 in Flaherty’s last 5 starts. Chicago has stayed Under in 3 straight. Ride the trend.

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