June 29, 2026, 3:54 p.m. ET

The Los Angeles Angels (36-49) and the Seattle Mariners (42-43) open a 3-game series Monday at T-Mobile Park in Seattle, Washington. First pitch is scheduled for 9:40 p.m. ET. Let’s analyze MLB odds around the Angels vs. Mariners odds and make our expert MLB picks and predictions for the best bets.

Season series: Angels lead 2-1

The Angels won 2 of 3 games in the first series in Anaheim April 3-5, with both wins coming by 1 run. The Under cashed in 2 of the 3 outings.

The Angels took 2 of 3 games from the A’s over the weekend in Anaheim, cashing the Under in the final 2 games. It won Sunday by a 4-1 score as slight underdogs (-106) as the Under (9.5) cashed. CF Josh Lowe had the big blow with a 2nd-inning grand slam in 2 at-bats.

The Mariners suffered 2 losses in 3 games in Cleveland over the weekend, and they’ve dropped the past 3 series since June 19. Seattle fell 6-5 as a slight dog (+102) on Sunday despite collecting 13 hits. 1B Josh Naylor was a bright spot with a 2 for 4 game, posting the only extra-base hit (a double) with a run scored and an RBI. CF Julio Rodriguez went 2 for 4 with a run scored, an RBI and a stolen base.

Watch MLB on Fubo!Angels at Mariners projected starters

RHP Ryan Johnson vs. RHP George Kirby

Johnson (1-2, 8.84 ERA) makes his fourth start seventh appearance). He has a 1.71 WHIP, 4.2 BB/9 and 7.0 K/9 in 19 1/3 innings.

Last start: Win, 6 IP, 0 ER, 1 H, 1 BB, 8 K in 5-1 home victory vs. Baltimore Orioles on Tuesday2026 road splits (2 starts): 0-2, 11.88 ERA (8 1/3 IP, 11 ER), 3 HR, 5 BB, 4 K, 2.40 WHIPCareer vs. Mariners (1 relief appearance): 1 IP, 1 ER, 3 H, 1 BB, 1 K, 4.00 WHIP, 9.0 K/9

Kirby (6-7, 3.94 ERA) makes his 17th start. He has a 1.34 WHIP, 2.2 BB/9 and 7.9 K/9 in 96 innings.

Last start: Win, 6 IP, 2 R (1 ER), 9 H, 2 BB, 5 K in 3-2 road win vs. Pittsburgh Pirates on TuesdayJune 2026 splits (4 starts): 1-3, 4.50 ERA (22 IP, 11 ER), 2 HR, 6 BB, 25 K, 1.77 WHIP2026 home splits (9 starts): 3-4, 4.56 ERA (53 1/3 IP, 27 ER), 7 HR, 13 BB, 48 K, 1.28 WHIPCareer vs. Angels (11 starts): 7-4, 3.41 ERA (66 IP, 25 ER), 10 HR, 10 BB, 85 K, 0.94 WHIP, 11.6 K/9Angels at Mariners odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 3:45 p.m. ET.

Moneyline (ML): Angels +170 (bet $100 to win $170) | Mariners -210 (bet $210 to win $100)Run line (RL)/Against the spread (ATS): Angels +1.5 (-120) | Mariners -1.5 (+100)Over/Under (O/U): 7.5 (O: -118 | U: -102)

Slide into: BaseballHQ.com for your fantasy baseball news. For decades, BHQ has been helping players just like you win! BHQ offers full-season subscriptions. Sign up today!

Angels at Mariners picks and predictionsPrediction

Mariners 5, Angels 2

The Mariners (-210) will set you back more than 2 times your potential return, and that’s way too expensive for a standalone bet.

Instead, look to the run line, which is much more economical.

PASS.

Let’s back MARINERS -1.5 (+100) at even-money laying the run and a half. There is plenty of risk here, as the Angels have won 2 of the first 3 meetings this season. However, the Mariners are a solid play at T-Mobile Park, especially with Kirby on the hill against the team which strikes out the most in the majors.

UNDER 7.5 (-102) is worth a look in this series opener, but take it easy.

The Under is 6-2 in the past 8 games for the Mariners and 4-2 in their past 6 home outings. The Under is 5-4-2 in the past 11 starts with Kirby on the bump, too.

For the Angels, the Under cashed in the final 2 games of their series against the A’s. The Under is 9-4 in Los Angeles’ past 13 games, too, and 12-5 across the club’s previous 17 outings.

Betting odds calculator

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow SportsbookWire on Twitter/X and like us on Facebook.

Our editors independently choose our recommendations. Some content is produced with paid support from a third party, however our editorial decisions remain independent. If you buy through our links, the USA TODAY Network may earn a commission. Prices and availability may change.

Gambling involves risk. Please only gamble with funds that you can comfortably afford to lose.  While we do our utmost to offer good advice and information we cannot be held responsible for any loss that may be incurred as a result of gambling.  We do our best to make sure all the information that we provide on this site is correct. However, from time to time mistakes will be made and we will not be held liable. Please check any stats or information if you are unsure how accurate they are. No guarantees are made with regards to results or financial gain. All forms of betting carry financial risk and it is up to the individual to make bets with or without the assistance of information provided on this site and we cannot be held responsible for any loss that may be incurred as a result of following the betting tips provided on this site.  Past performances do not guarantee success in the future and betting odds fluctuate from one minute to the next. The material contained on this site is intended to inform, entertain and educate the reader and in no way represents an inducement to gamble legally or illegally or any sort of professional advice.

Gannett may earn revenue from sports betting operators for audience referrals to betting services. Sports betting operators have no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. Terms apply, see operator site for Terms and Conditions. If you or someone you know has a gambling problem, help is available. Call the National Council on Problem Gambling 24/7 at 1-800-GAMBLER (NJ, OH), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA), 1-800-9-WITH-IT (IN). Must be 21 or older to gamble. Sports betting and gambling are not legal in all locations. Be sure to comply with laws applicable where you reside. It is your sole responsibility to act in accordance with your local laws.

Prediction Markets: Certain prediction markets are event contracts regulated by the U.S. Commodity Futures Trading Commission (CFTC) or other applicable regulatory authorities and are legally distinct from traditional gambling and sports betting. Eligibility requirements to participate in prediction markets differ from those for sports betting and gambling — you may be required to be 18 or older (or such other age as the applicable platform requires) and to satisfy other eligibility criteria established by the relevant platform and governing law. Prediction market trading involves financial risk and may not be available in all jurisdictions. The legal and regulatory status of prediction markets varies by jurisdiction and by platform. It is your sole responsibility to confirm that participation is lawful where you reside and to comply with all applicable laws and platform terms.