Guardians vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 14

Odds updated as of 2:12 a.m.

On Monday in MLB, the Cleveland Guardians are up against the Chicago White Sox.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here’s what you need to know.

Cleveland Guardians (76-74) vs. Chicago White Sox (76-73)Date: Monday, September 14, 2026Time: 6:40 p.m. ETVenue: Progressive Field — Cleveland, OhioCoverage: CleGuardians.TV and CHSNAll MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.Moneyline: CLE: (-144) | CHW: (+122)Spread: CLE: -1.5 (+162) | CHW: +1.5 (-196)Total: 7.5 — Over: (+112) | Under: (-138)

Probable Pitchers: Gavin Williams (Guardians) – 13-7, 3.78 ERA vs Sean Newcomb (White Sox) – 2-4, 2.77 ERA

This contest’s pitching matchup is set, as the Guardians will send Gavin Williams (13-7) to the mound, while Sean Newcomb (2-4) will answer the bell for the White Sox. Williams’ team is 14-14-0 against the spread in his starts this season. Williams’ team has been victorious in 60.9% of the games he’s started as the moneyline favorite with a record of 14-9. The White Sox have gone 3-2-0 ATS in Newcomb’s five starts that had a set spread. The White Sox have a 2-1 record in Newcomb’s three starts this season when they were the underdog on the moneyline.

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (50.6%)

The Guardians vs White Sox moneyline has Cleveland as a -144 favorite, while Chicago is a +122 underdog on the road.The White Sox are +1.5 on the spread (-196 to cover), and Cleveland is +162 to cover the runline.The Guardians-White Sox game on Sept. 14 has been given an over/under of 7.5 runs. The over is set at +112 and the under at -138.

Bet on Cleveland Guardians vs. Chicago White Sox on FanDuel today!

The Guardians have come away with 43 wins in the 84 contests they have been listed as the favorites in this season.Cleveland has a record of 18-10 in contests when sportsbooks favor them by -144 or more on the moneyline.The Guardians and their opponents have gone over the total this season in 69 of their 142 opportunities.In 142 games with a line this season, the Guardians have a mark of 67-75-0 against the spread.The White Sox have been the underdog on the moneyline 102 total times this season. They’ve gone 49-53 in those games.Chicago has a 23-27 record (winning 46% of its games) when it has played as a moneyline underdog of +122 or longer.The White Sox have combined with opponents to hit the over on the total 80 times this season for an 80-65-1 record against the over/under.The White Sox have collected an 81-65-0 record against the spread this season.Chase DeLauter leads Cleveland in total hits (134) this season while batting .291 with 45 extra-base hits. He has an on-base percentage of .363 and a slugging percentage of .456.He is 12th in batting average, 25th in on-base percentage, and 42nd in slugging among qualified hitters in MLB.Steven Kwan leads the Guardians with an OPS of .721. He has a slash line of .278/.375/.346 this season.His batting average ranks 26th among qualified players, his on-base percentage 10th, and his slugging percentage 130th.Kwan enters this game looking to extend his seven-game hit streak. During his last 10 games he is hitting .317 with four doubles, a home run, four walks and three RBIs.Jose Ramirez has 98 hits this season and has a slash line of .230/.320/.363.Brayan Rocchio has 13 home runs, 65 RBI and a batting average of .246 this season.Miguel Vargas has 135 hits, a team-high for the White Sox. He’s batting .247 and slugging .470 with an on-base percentage of .355.Including all qualified players, he is 85th in batting average, while his on-base percentage ranks 38th and he is 31st in slugging.Vargas hopes to build on a three-game hitting streak in this matchup. During his last five outings he is batting .150 with a walk.Sam Antonacci has a .366 OBP to lead his team. He has a batting average of .269 while slugging .393.Including all qualifying hitters, he is 43rd in batting average, 20th in on-base percentage and 97th in slugging percentage.Chase Meidroth has a slugging percentage of .398, a team-high for the White Sox.Tristan Peters is hitting .279 with 31 doubles, four triples, 12 home runs and 34 walks.8/9/2026: 5-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +116)8/8/2026: 6-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +116)8/7/2026: 8-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +126)7/4/2026: 3-1 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)7/3/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)7/2/2026: 6-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)6/24/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)6/23/2026: 2-1 CHW (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -112, Underdog Moneyline: -104)6/22/2026: 6-5 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)9/14/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)

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