Cubs vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 20

Odds updated as of 6:11 a.m.

The Sunday slate in MLB includes a matchup between the Chicago Cubs and the Cincinnati Reds.

We’ve got you covered, in terms of the most important info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Chicago Cubs (86-69) vs. Cincinnati Reds (72-83)Date: Sunday, September 20, 2026Time: 1:40 p.m. ETVenue: Great American Ball Park — Cincinnati, OhioCoverage: Reds.TV and MARQCubs vs Reds Odds & MoneylineAll MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.Moneyline: CHC: (-154) | CIN: (+130)Spread: CHC: -1.5 (+105) | CIN: +1.5 (-126)Total: 10.5 — Over: (+112) | Under: (-138)Cubs vs Reds Probable Starting Pitchers

Probable Pitchers: David Peterson (Cubs) – 8-8, 5.11 ERA vs Rhett Lowder (Reds) – 6-11, 5.79 ERA

The Cubs will call on David Peterson (8-8) versus the Reds and Rhett Lowder (6-11). Peterson and his team have a record of 9-11-0 against the spread when he starts. Peterson’s team has won 54.5% of his starts when they are favored on the moneyline (6-5). The Reds have an 11-12-0 ATS record in Lowder’s 23 starts that had a set spread. The Reds are 10-10 in Lowder’s 20 starts this season that they were the underdog on the moneyline.

Cubs vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (65.4%)

Chicago is a -154 favorite on the moneyline, while Cincinnati is a +130 underdog at home.The Cubs are favored by 1.5 runs on the road versus the Reds. The Cubs are +105 to cover the spread, while the Reds are -126.Cubs versus Reds, on Sept. 20, has an over/under of 10.5, with the over being +112 and the under -138.

Bet on Chicago Cubs vs. Cincinnati Reds on FanDuel today!

Cubs vs Reds Betting TrendsThe Cubs have been victorious in 58, or 56.9%, of the 102 contests they have been chosen as favorites in this season.Chicago has a record of 27-13 in contests when oddsmakers favor them by -154 or more on the moneyline.The Cubs and their opponents have gone over in 85 of their 150 games with a total set by sportsbooks this season.The Cubs have an against the spread record of 72-78-0 in 150 games with a line this season.The Reds have won 46.7% of the games this season they were the underdog on the moneyline (50-57).When it has played as a moneyline underdog with odds of +130 or longer, Cincinnati has gone 14-24 (36.8%).The Reds have played in 151 games with a set over/under, and have combined with their opponents to go over the total 80 times (80-69-2).The Reds have a 77-74-0 record against the spread this season (covering 51% of the time).Cubs Player LeadersPete Crow-Armstrong leads Chicago with 167 hits and an OBP of .369, plus a team-best slugging percentage of .571. He’s batting .277.Among qualifying hitters in MLB, he is 27th in batting average, 16th in on-base percentage, and second in slugging.Alex Bregman is hitting .260 with 32 doubles, two triples, 26 home runs and 74 walks. He’s slugging .451 with an on-base percentage of .350.His batting average is 64th among qualified players, his on-base percentage 42nd, and his slugging percentage 45th.Nico Hoerner has collected 160 base hits, an OBP of .316 and a slugging percentage of .356 this season.Hoerner brings a two-game hitting streak into this game. During his last five outings he is batting .250 with a double and two RBIs.Seiya Suzuki is batting .267 with a .366 OBP and 84 RBI for Chicago this season.Suzuki has hit safely in two games in a row. During his last five outings he is hitting .238 with a walk and three RBIs.Reds Player LeadersSal Stewart has a .473 slugging percentage, which leads the Reds. He’s batting .269 with an on-base percentage of .336.Including all qualifying players in the majors, his batting average places him 43rd, his on-base percentage ranks 62nd, and he is 30th in slugging.Elly De La Cruz has racked up 152 hits with a .367 on-base percentage to lead his team in both. He has a batting average of .286 while slugging .517.Including all qualified players, he ranks 14th in batting average, 18th in on-base percentage and 10th in slugging percentage.JJ Bleday is batting .214 with 16 doubles, two triples, 22 home runs and 70 walks.Eugenio Suarez has 17 doubles, 24 home runs and 52 walks while hitting .209.Cubs vs Reds Head to Head9/19/2026: 5-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -146, Underdog Moneyline: +124)9/18/2026: 6-4 CIN (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)8/30/2026: 7-5 CIN (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +142)8/29/2026: 17-5 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -205, Underdog Moneyline: +190)8/28/2026: 10-8 CIN (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -190, Underdog Moneyline: +176)7/12/2026: 8-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)7/11/2026: 5-3 CHC (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)7/10/2026: 4-0 CIN (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)5/7/2026: 8-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -198, Underdog Moneyline: +166)5/6/2026: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -168, Underdog Moneyline: +142)

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