Owolabi MO, Thrift AG, Mahal A, Ishida M, Martins S, Johnson WD, et al. Primary stroke prevention worldwide: translating evidence into action. Lancet Public Health. 2022;7:e74–e85.
Kuriakose D, Xiao Z. Pathophysiology and treatment of stroke: present status and future perspectives. Int J Mol Sci. 2020;21:7609.
Sposato LA, Saposnik G. Gross domestic product and health expenditure associated with incidence, 30-day fatality, and age at stroke onset: a systematic review. Stroke. 2012;43:170–7.
Shi K, Tian DC, Li ZG, Ducruet AF, Lawton MT, Shi FD. Global brain inflammation in stroke. Lancet Neurol. 2019;18:1058–66.
Mracsko E, Veltkamp R. Neuroinflammation after intracerebral hemorrhage. Front Cell Neurosci. 2014;8:388.
Jayaraj RL, Azimullah S, Beiram R, Jalal FY, Rosenberg GA. Neuroinflammation: friend and foe for ischemic stroke. J Neuroinflamm. 2019;16:142.
Jurcau A, Simion A. Neuroinflammation in cerebral ischemia and ischemia/reperfusion injuries: from pathophysiology to therapeutic strategies. Int J Mol Sci. 2021;23:14.
Li J, Cao F, Yin HL, Huang ZJ, Lin ZT, Mao N, et al. Ferroptosis: past, present and future. Cell Death Dis. 2020;11:88.
Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149:1060–72.
Cui Y, Zhang Y, Zhao X, Shao L, Liu G, Sun C, et al. Acsl4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation. Brain Behav Immun. 2021;93:312–21.
Alim I, Caulfield JT, Chen Y, Swarup V, Geschwind DH, Ivanova E, et al. Selenium drives a transcriptional adaptive program to block ferroptosis and treat stroke. Cell. 2019;177:1262–79.e1225.
Chen X, Kang R, Kroemer G, Tang D. Ferroptosis in infection, inflammation, and immunity. J Exp Med. 2021;218:e20210518.
Yu Y, Yan Y, Niu F, Wang Y, Chen X, Su G, et al. Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases. Cell Death Discov. 2021;7:193.
Wang F, He J, Xing R, Sha T, Sun B. Molecular mechanisms of ferroptosis and their role in inflammation. Int Rev Immunol. 2023;42:71–81.
Zhao Z, Wu J, Xu H, Zhou C, Han B, Zhu H, et al. Xjb-5-131 inhibited ferroptosis in tubular epithelial cells after ischemia-reperfusion injury. Cell Death Dis. 2020;11:629.
Krause C, Geissler C, Tackenberg H, El Gammal AT, Wolter S, Spranger J, et al. Multi-layered epigenetic regulation of IRS2 expression in the liver of obese individuals with type 2 diabetes. Diabetologia. 2020;63:2182–93.
Hashimoto S, Kubota N, Sato H, Sasaki M, Takamoto I, Kubota T, et al. Insulin receptor substrate-2 (irs2) in endothelial cells plays a crucial role in insulin secretion. Diabetes. 2015;64:876–86.
Sadagurski M, Leshan RL, Patterson C, Rozzo A, Kuznetsova A, Skorupski J, et al. Irs2 signaling in lepr-b neurons suppresses foxo1 to control energy balance independently of leptin action. Cell Metab. 2012;15:703–12.
Manchenkov T, Pasillas MP, Haddad GG, Imam FB. Novel genes critical for hypoxic preconditioning in zebrafish are regulators of insulin and glucose metabolism. G3 (Bethesda). 2015;5:1107–16.
Baquedano E, Burgos-Ramos E, Canelles S, Gonzalez-Rodriguez A, Chowen JA, Argente J, et al. Increased oxidative stress and apoptosis in the hypothalamus of diabetic male mice in the insulin receptor substrate-2 knockout model. Dis Model Mech. 2016;9:573–83.
Spielman LJ, Bahniwal M, Little JP, Walker DG, Klegeris A. Insulin modulates in vitro secretion of cytokines and cytotoxins by human glial cells. Curr Alzheimer Res. 2015;12:684–93.
Zhang X, Hu L, Xu S, Ye C, Chen A. Erianin: A direct NLRP3 inhibitor with remarkable anti-inflammatory activity. Front Immunol. 2021;12:739953.
Fu X, Chen S, Xian S, Wu Q, Shi J, Zhou S. Dendrobium and its active ingredients: emerging role in liver protection. Biomed Pharmacother. 2023;157:114043.
Li C, Sun X, Song Z, Sun J, Li Y, Wang N, et al. Chemical constituents from the stems of dendrobium gratiosissimum and their biological activities. Phytochemistry. 2022;201:113260.
Li Z, Xiang J, Hu D, Song B. Naturally potential antiviral agent polysaccharide from dendrobium nobile lindl. Pestic Biochem Physiol. 2020;167:104598.
Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke. 1986;17:472–6.
Chen J, Li Y, Wang L, Zhang Z, Lu D, Lu M, et al. Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke. 2001;32:1005–11.
Yang LC, Li J, Xu SF, Cai J, Lei H, Liu DM, et al. L-3-n-butylphthalide promotes neurogenesis and neuroplasticity in cerebral ischemic rats. CNS Neurosci Ther. 2015;21:733–41.
Sung PH, Lee FY, Lin LC, Chen KH, Lin HS, Shao PL, et al. Melatonin attenuated brain death tissue extract-induced cardiac damage by suppressing damp signaling. Oncotarget. 2018;9:3531–48.
Yao H, Ke H, Zhang X, Pan SJ, Li MS, Yang LP, et al. Molecular recognition of hydrophilic molecules in water by combining the hydrophobic effect with hydrogen bonding. J Am Chem Soc. 2018;140:13466–77.
Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001;414:799–806.
Guo S, Mangal R, Dandu C, Geng X, Ding Y. Role of forkhead box protein o1 (Foxo1) in stroke: a literature review. Aging Dis. 2022;13:521.
Wang L, Zhang X, Xiong X, Zhu H, Chen R, Zhang S, et al. Nrf2 regulates oxidative stress and its role in cerebral ischemic stroke. Antioxidants. 2022;11:2377.
Ridder DA, Schwaninger M. Nf-kappab signaling in cerebral ischemia. Neuroscience. 2009;158:995–1006.
Jiang X, Stockwell BR, Conrad M. Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol. 2021;22:266–82.
Tang LJ, Zhou YJ, Xiong XM, Li NS, Zhang JJ, Luo XJ, et al. Ubiquitin-specific protease 7 promotes ferroptosis via activation of the p53/tfr1 pathway in the rat hearts after ischemia/reperfusion. Free Radic Biol Med. 2021;162:339–52.
Ursini F, Maiorino M. Lipid peroxidation and ferroptosis: the role of gsh and gpx4. Free Radic Biol Med. 2020;152:175–85.
Campbell BCV, Khatri P. Stroke. Lancet. 2020;396:129–42.
Zhu H, Hu S, Li Y, Sun Y, Xiong X, Hu X, et al. Interleukins and ischemic stroke. Front Immunol. 2022;13:828447.
Hu X, Li P, Guo Y, Wang H, Leak RK, Chen S, et al. Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia. Stroke. 2012;43:3063–70.
Maida CD, Norrito RL, Daidone M, Tuttolomondo A, Pinto A. Neuroinflammatory mechanisms in ischemic stroke: focus on cardioembolic stroke, background, and therapeutic approaches. Int J Mol Sci. 2020;21:6454.
Xu L, Zeng X, Liu Y, Wu Z, Zheng X, Zhang X. Effect of dendrobium officinale polysaccharides on central nervous system disease: based on gut microbiota. Int J Biol Macromol. 2023;240:124440.
Liang J, Chen S, Chen J, Lin J, Xiong Q, Yang Y, et al. Therapeutic roles of polysaccharides from dendrobium officinaleon colitis and its underlying mechanisms. Carbohydr Polym. 2018;185:159–68.
Wu Y, Li Y, Jin XM, Dai GH, Chen X, Tong YL, et al. Effects of granule dendrobii on chronic atrophic gastritis induced by N-methyl-N’-nitro-N-nitrosoguanidine in rats. World J Gastroenterol. 2022;28:4668–80.
Muir KW, Tyrrell P, Sattar N, Warburton E. Inflammation and ischaemic stroke. Curr Opin Neurol. 2007;20:334–42.
McColl BW, Allan SM, Rothwell NJ. Systemic infection, inflammation and acute ischemic stroke. Neuroscience. 2009;158:1049–61.
Lao-PeregrÃn C, Ballesteros JJ, Fernández M, Zamora-Moratalla A, Saavedra A, Gómez Lázaro M, et al. Caffeine-mediated bdnf release regulates long-term synaptic plasticity through activation of IRS2 signaling. Addict Biol. 2017;22:1706–18.
Mishra N, Lata S, Deshmukh P, Kamat K, Surolia A, Banerjee T. Insulin signaling pathway protects neuronal cell lines by Sirt3 mediated IRS2 activation. Biofactors. 2018;44:224–36.
Ruan H, Luo J, Wang L, Wang J, Wang Z, Zhang J. Sika deer antler protein against acetaminophen-induced nephrotoxicity by activating Nrf2 and inhibition Foxo1 via PI3k/Akt signaling. Int J Biol Macromol. 2019;141:961–87.
Zhang Y, Lu X, Tai B, Li W, Li T. Ferroptosis and its multifaceted roles in cerebral stroke. Front Cell Neurosci. 2021;15:615372.
Jin Y, Zhuang Y, Liu M, Che J, Dong X. Inhibiting ferroptosis: a novel approach for stroke therapeutics. Drug Discov Today. 2021;26:916–30.