The Yankees are set to face an immediate test in the ALDS.

The Tampa Bay Rays plan to start ace Drew Rasmussen in Game 1 on Saturday night at Tropicana Field, manager Kevin Cash confirmed to reporters.

While expected, the decision is notable because Rasmussen — beyond being one of MLB’s best pitchers — is a notorious Yankee killer.

In his career against the Yankees, the right-handed Rasmussen is 5-2 with a 1.81 ERA over 11 appearances (10 starts).

That includes four starts this year, when Rasmussen went 2-1 with a 2.86 ERA and 26 strikeouts in 22 innings.

The best of those outings happened last week at Yankee Stadium, where Rasmussen took a no-hitter into the seventh and finished with 11 strikeouts over 6.2 innings of one-run ball.

Overall, Rasmussen went 16-5 with a 2.67 ERA and an American League-best 0.91 WHIP in 30 starts in the regular season.

Rasmussen earned the Game 1 nod over fellow right-handers Nick Martinez (15-6, 3.10 ERA) and Freddy Peralta (0.96 ERA in five September starts). Tampa Bay has not announced its ALDS rotation beyond Game 1.

“I wish I could say it’s just baseball, but obviously there’s just a little bit more to it — a little bit more excitement, a little bit more adrenaline,” Rasmussen recently told MLB.com, before knowing which team he would face in the ALDS.

“But, in all honesty, the preparation doesn’t change. There’s still a job to do, and then at the end of the day, all you’re trying to do is give your team a chance to win.”

The Yankees did not reveal their Game 1 starter after completing a two-game sweep of the Boston Red Sox in the Wild Card Series.

Because that series didn’t require a third game, that night’s would-be starter Gerrit Cole (10-9, 3.61 ERA) is available for Game 1. The other candidate is left-hander Carlos Rodón (7-3, 2.67 ERA), whom the Yankees didn’t need to use in relief against Boston.

Game 1 figures to be pivotal for both teams, as the Yankees will likely turn to AL Cy Young Award favorite Cam Schlittler (14-6, 1.95 ERA) for Game 2.

Schlittler — who pitched 6.1 scoreless innings in a Wild Card Game 1 victory — would be lined up for a potential winner-take-all Game 5 as well.

For the Rays, that increases the importance of taking advantage of Rasmussen’s starts, beginning with Game 1.

“He’s the standard,” Rays pitching coach Kyle Snyder told MLB.com. “He brings it all to the table, and I mean that. For me, he is the standard. If somebody wants to know what success looks like, you don’t have to look too far.”

With the extra off-days, the Yankees and Rays could use only three starters in the series without anyone having to pitch on extra rest.

After a six-inning, one-run gem against Boston, left-hander Max Fried (5-5, 2.80) is certain to start one of the middle games for the Yankees.