The Seattle Mariners (32-29) visit the Los Angeles Angels (28-33) to open a 3-game series Friday. First pitch from Angel Stadium is at 9:38 p.m. ET. Let’s analyze BetMGM Sportsbook’s MLB odds around the Mariners vs. Angels odds and make our expert MLB picks and predictions for the best bets.

Season series: Mariners lead 2-0

The Mariners wrapped up a disappointing homestand Thursday with a 4-3 loss to the Baltimore Orioles, as the visitors completed a 3-game sweep. Seattle has now dropped 7 of its last 10 overall and went just 3-6 during the 9-game stretch at T-Mobile Park. SP Bryan Woo was tagged for 4 runs on 6 hits over 5 innings, including home runs by DH Adley Rutschman and SS Gunnar Henderson.

The Angels went 3-3 on their recent road trip and have dropped 8 of their last 11 overall, though they did take 2 of 3 from the Boston Red Sox in their most recent series. They dropped the finale 11-9 Wednesday, despite a strong showing from OF Taylor Ward, who hit his 17th home run and drove in 4 runs. RP Brock Burke took the loss after surrendering a walk-off 2-run homer to OF Ceddanne Rafaela.

Mariners at Angels projected starters

RHP Bryce Miller vs. RHP Kyle Hendricks

Miller (2-4, 5.36 ERA) makes his 10th start. He has a 1.53 WHIP, 4.5 BB/9 and 7.6 K/9 through 43 2/3 innings.

Last start: No-decision, 4 IP, 3 ER, 5 H, 1 BB, 2 K in 5-4 home win in 11 innings over Minnesota Twins Saturday2025 road splits: 1-2, 5.68 ERA (19 IP, 12 ER), 1.63 WHIP, 8.1 K/9 in 4 startsLast start vs. Angels: Win, 5 IP, 0 ER, 2 K, 5 BB, 6 K in 5-3 win in Seattle April 29Career vs. Angels: 2-1, 1.30 ERA (27 2/3 IP, 4 ER), 0.94 WHIP, 11.1 K/9 in 5 starts

Hendricks (2-6, 5.34 ERA) makes his 12th start. He has a 1.29 WHIP, 2.7 BB/9 and 5.9 K/9 through 59 innings.

Last start: No-decision, 5 2/3 IP, 4 ER, 7 H, 2 BB, 6 K in 7-5 road loss to Cleveland Guardians SaturdayAngels have lost 4 of his last 5 starts2025 home splits: 1-3, 3.80 ERA (23 2/3 IP, 10 ER), 1.10 WHIP, 5.3 K/9 in 4 startsCareer vs. Mariners: 1 home start (Sept. 2, 2019), no-decision, 6 IP, 1 ER, 3 H, 1 BB, 7 K in 5-1 victory with Chicago Cubs

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Mariners at Angels odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:22 a.m. ET.

Moneyline (ML): Mariners -135 (bet $135 to win $100) | Angels +115 (bet $100 to win $115)Run line (RL)/Against the spread (ATS): Mariners -1.5 (+125) | Angels +1.5 (-150)Over/Under (O/U): 9 (O: -120 | U: +100)Mariners at Angels picks and predictionsPrediction

Angels 4, Mariners 3

The Mariners are 16-12 on the road, while the Angels have struggled at home (10-15), but Seattle has been held to 3 runs or fewer in 4 straight games and 8 of its last 11.

But Miller has fared well against the Angels in his career, allowing just 4 earned runs over 27 2/3 innings. That includes 5 shutout innings in Seattle April 29, when the Mariners won 5-3.

Hendricks has been much more effective at home than on the road.

The Angels averaged 5.2 runs per game during their 6-game road trip.

BET ANGELS (+115).

Seventeen of the Angels’ last 19 covers have also been outright victories.

Ten of the Mariners’ last 12 ATS losses have also been outright defeats.

With plus money on the Angels’ ML as underdogs, that’s the better value play.

PASS.

Of the 2 meetings in April, one featured 8 total runs and the other had 12.

The Mariners’ last 5 games have not surpassed 9 total runs.

Eight of the Angels’ last 11 games have not surpassed 9 runs.

BET UNDER 9 (+100).

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